| Project/Area Number |
07557190
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya City University |
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Principal Investigator |
FURUYAMA Fujiya Nagoya City Univ.Med.Sch., Assis.Prof., 医学部, 講師 (00080101)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURADA Sotaro Kanazawa University, Fac.Med., Assis.Prof., 医学部, 講師 (00215691)
YAHATA Takehiro Nayoro City Col., Sch.Nurs., Prof., 看護学科, 教授 (60041828)
KUROSHIMA Akira Asahikawa Med.Col., Prof., 医学部, 教授 (90002774)
TANAKA Etsuro Tokai Univ.Sch.Med., Assis.Prof., 医学部, 講師 (80211366)
SHIDO Osamu Kanazawa University, Fac.Med., Asso.Prof., 医学部, 助教授 (40175386)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1996: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | the FOK rat / body temperature regulation / heat adaptation / heat resistance / cold resistance / superior salivatory nucleus / salivation / brown adipose tissue / FOK rat,inbred / Body Temperature Regulations / Submandibular Gland / the FOK rat / genotypic heat adaptation / heat loss / β-adrenergic receptor / heat resistance / cold resistance / body temperature regulation / brown adipose tissue / thermoregulation / energy metabolism |
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| Research Abstract |
AIM The FOK rat had been selected for heat tolerance and inbred.
In the preseent study, it was aimed to study a wide range of characteristics of the FOK rat for the purpose of multiple use the inbred as an experimental animal.
RESULTS
1.FOK rats secreted highly larger amount of saliva in response to heat from subman dibular glands than the other strains. It was suggested that the thermal salivation is induced by signals come from hypothalamus-superior salivatory nucleus to subman dibular gland. Subman dibular gland of the FOK rat was larger than those of the other strains.
2.Thermo genesis in brown adipocytes of the FOK rat was not activated at 37.0ﾟC and 39.9ﾟC by a low concentraition of b-agon ist (10^<-9> M isoproterenol) by which it was activated in the other strains.
3.In the thermo neutral zone, thermo effector thresh olds and preferred ambient temperature was lower in the FOK rat than those in the other strains.
4.The FOK rat was resistant to cold environment.
CONCLUSION The heat resistant FOK rats were also cold resistant and significantly different from other stains in the thermo neutral zone. It can be expected for the FOK rat to be a experimental animal model for multiple use.
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