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Control of Echinococcus multilocularis in rural area by anthelminthics application for definitive hosts

Research Project

Project/Area Number 07557204
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 寄生虫学(含医用動物学)
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

OKU Yuzaburo  Hokkaido Univ.Grad.School of Vet.Med., Assoc.Prof., 大学院・獣医学研究科, 助教授 (60133716)

Co-Investigator(Kenkyū-buntansha) NONAKA Nariaki  Hokkaido Univ.Grad.School of Vet.Med., Instr., 大学院・獣医学研究科, 助手 (50281853)
KAMIYA Masao  Hokkaido Univ.Grad.School of Vet.Med., prof., 学院・獣医学研究科, 教授 (30081665)
岡本 宗裕  大阪大学, 医学部, 助手 (70177096)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1997: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1996: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsEchinococcus multilocularis / Foxes / Rural Area / Hokkaido / Coproantigen / Praziquantel / Zoonoses / Control / プラジクアンテル / コントロール / イヌ / 糞便抗原 / プラジカルテル / 人畜共通感染症 / プラジカンテル
Research Abstract

Echinococcus multilocularis is one of the most important zoonotic parasites distributed in Hokkaido. In 1996, the prevalence of the parasite in foxes reached to 40%. Three surveys for E.multilocularis in definitive hosts were carried out in Shiretoko (National Park), Koshimizu (Rural area) and Sapporo (Urban area).
First survey was conducted in the Shiretoko National Park to apply coproantigen detection method in monitoring for the prevalence at touring spots where close contact between human and foxes are frequently observed. In this area, 8 fox family territories have been determined. Detection of coproantigen and eggs was mostly restricted in one family, suggesting the prevalence in Shiretoko was very low. The second study was conducted in Koshimizu. In total 168 fox dens were found in about 200km^2 study area and 31 fox families living there. Faeces collected around dens were 48.5% coproantigen positive. These suggested high prevalence in Koshimizu and higher prevalence in pups. In the two decades, red foxes have been observed in urban area in Hokkaido. This cause a serious public health thread. In the third study, the distribution of foxes in the urban area (242.4km^2) of Sapporo were investigated. In winter, fox trails on the snow were checked at 130 parks and woodland areas distributed evenly in urban area. It is showed that foxes were all over the urban area, but were not evenly distributed. Foxes inhabited densely the urban peripheral area. Fox breeding dens were found at 17 spots in and around the urban area. Fox feces were collected around the dens and were checked for the Echinococcus infection by the coproantigen detection method. Coproantigen positive feces were found at 7 spots. This shows that the foxes infected E.multilocularis have invaded into the urban area.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] 神谷 正男: "新たな様相を示すエキノコックス症-感染源対策へ向けて" 最新医学. 52. 81-87 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 神谷 正男: "エキノコックスの環境適応性ならびに防除法,とくに感染源対策" 日本学術会議北海道地区ニュース. 6-7 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 神谷 正男: "エキノコックス症〜特に感染源対策は向けて〜" 科学療法の領域. 13. 214-219 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 奥 祐三郎: "多包条虫の流行状況の悪化" 臨床獣医. 15. 26-32 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsukada, H.: "Foraging behavior of red foxes Vulpes vulpes schrencki utilizing human food in the Shiretoko National Park,Hokkaido" Mammal Study. 21. 137-151 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] konno, K., et al: "Effect of ultaviolet radiation on the infectivity of Taenia taeniaeformis eggs." Jpn.J.Vet.Res.45. 75-79 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] KAMlYA,M.: "New phase of spreading echinococcosis and its control measure by targeting definitive host." Saishin-Igaku. 52. 81-87 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] KAMlYA,M.: "Environmental adaptation and control of Echinococcus multilocularis, -its control measure by targeting definitive host-." News in Hokkaido, Nihon-gakujyutsu-kaigi. 6-7 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] KAMlYA,M.: "Alveolar Echinococcosis, -its control measure in definitive host-." Antibiotics & Chemotherapy. 13. 214-219 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] OKU,Y.: "Spreading distribution and increasing prevalence of Echinococcus multilocularis in Hokkaido, Japan." J.Clin.Vet.Med.15. 26-32 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] TSUKADA,H.& N.NONAKA: "Foraging behavior of red foxes Vulpes vulpes schrencki utilizing human food in the Shiretoko National Park, Hokkaido." Mammal Study. 21. 137-151 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] KONNO,K.: "Effect of ultravioletradiation on the infectivity of Taenia taeniaeformis eggs." Japanese Journal of Veterinary Research. 45. 75-79 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 神谷正男: "新たな様相を示すエキノコックス症-感染源対策へ向けて" 最新医学. 52. 81-87 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 神谷正男: "エキノコックスの環境適応性ならびに防除法,特に感染源対策" 日本学術会議北海道地区ニュース. 6-7 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 神谷正男: "エキノコックス症〜特に感染源対策は向けて〜" 科学療法の領域. 13. 214-219 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 奥 祐三郎: "多包条虫の流行状況の悪化" 臨床獣医. 15. 26-32 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsukada,H.: "Foraging behavior of red foxes Vulpes vulpes schrencki utilizing human food in the Shiretoko National Park,Hokkaido" Mammsl Study. 21. 137-151 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Konnno,K., et al.: "Effect of ultraviolet radiation on the infectivity of Taenia taeniaeformis eggs." Jpn.J.Vet.Res.45. 75-79 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] INOHARA. J.: "Acquired resistaance against adult Echinocossuc multilocularis infection observed in golder hamsters" Japanese Jounal of Parasitology. 45. 1-5 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] INOHARA, J.: "Parenteral strobilar development of Echinococcus multilocularis in scid mice" Japanese Journal of Veterinary Research. 44. 1-12 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] SAKAI, H.: "Echinococcus multilocularis coproantigen detection in golden hamster, an alternative definitive host" Experimental Animals. 45. 275-278 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] KAMIYA, M.: "Workshop summry : Zoonosis-environmental transmission as exemplified by echinococosis" Veterinary Parasitology. 64. 275-278 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] IWAKI, T.: "Developmental study of Taenisa mustelae in the intermediate and definitive hosts, with a note on the life cycle of T. mustelae in Hokkaido, Japan" Journal of Parasitology. 82. 840-842 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] SATO, H.: "Comparison of serodiagnostic tests and ultrasonography for cystic hydatidosis in an epidemiological study of ruraluruguay" Journal of Parasitology. 82. 852-854 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] NIONAKA, N.: "Time course of coproantigen excretion in Echinococcus multilocularis infections in foxes and an alternative definitive host, golden hamsters" International Journal for Parasitology. 26. 1271-1278 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] IWAKI, T.: "Infectivity to rats with eggs of the Echinococcus multilocularis isolate from a Norway rain Hokkaido, Japan." Japanese Journal of Parasitology. 44. 32-33 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] IWAKI, T.: "New distribution record of Taenia mustelae Gmelin,1790(Cestoda)from the least weasel Mustela nivalis in Hokkaido" Japanese Journal of Parasitology. 44. 796 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] KOHNO. H.: "Development and characterization of murine monoclonal antibodies to Echinococcus multilocularis adult worms and its use for the coproantigen detection" Japanese Journal of Parasitology. 44. 401-412 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] SAKASHITA, M.: "Detection of Echinococcus multilocularis coproantigens in experimentally infected dogs using murine monoclonal antibody against adult worms" Japanese Journal of Parasitology. 44. 413-420 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] SAKAI, H.: "An enzyme-linked immunosorbent assay(ELISA)for the detection of Echinococcus granulosus coproantigens in dogs" Japanese Journal of Parasitology. 44. 453-461 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] OKAMOTO, M.: "Phylogenetic relationships within Taenia taeniaseformis variants and taeniid cestodes inferred from the nucleotide sequence of the cytichrome c oxidase subunit I gene." Prasitology Research. 81. 451-458 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] KAKUDA, T.: "Participation of platelets in protection against larval Taenia taeniaeformis infection in mice" International Archives of Allelgy and Immunology. 109. 295-297 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] SAKAI, H.: "Echinococcus multilocularis coproantigen detection in golden hamster,an alternative definitive host" Experimental Animals. 45(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] INOHARA, I.: "Acquired resistance against adult Echinococcus multilocularis in fection observed in golden hamsters" Japanese Journal of Parasitology. 45(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] INOHARA, I.: "Parenteral strobilar development of Echinococcus multilocularis in SCID mice" Japanese Journal of Veterinary Research. 44(in press). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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