• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The roles of growth factors and cytokine in retinal neovascularization.

Research Project

Project/Area Number 07557263
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

SAITO Yoshihiro  Osaka University Medical School, Lecturer, 医学部, 講師 (40215570)

Co-Investigator(Kenkyū-buntansha) HAYASHI Atsushi  Osaka University Medical School, Assistant Professor, 医学部, 助手 (20283773)
OHJI Masahito  Osaka University Medical School, Assistant Professor, 医学部, 助手 (90252650)
TANO Yasuo  Osaka University Medical School, Professor, 医学部, 教授 (80093433)
石本 一郎  大阪大学, 医学部, 助教授 (80159780)
本倉 雅信  大阪大学, 医学部, 助手
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsneovascularization / Agerelated macular degeneration / thalidomide / laser / retina / bFGF / Diabetes / Retinopathy of prematurity / 加齢黄斑変性 / 脈絡膜 / 光化学療法 / フルオレスチンナトリウム
Research Abstract

We developed new animal models of ocular neovascularization. A rat model of subretinal neovascularization was made by a b-FGF containing pellet implanted between sensory retinal and retinal pigment epithelium. The subretinal neovascularization was very similar to human age-related macular degeneration histologically and histopathologically. Another model was preretinal neovascularization in rats, which was made by artificial retinal vein occlusion with photodynamic (Ar laser and fluorescein-Na) thrombosis in rat. This was the first rat model of preretinal neovascularization.
Thalidomide is a well known teratogen in human. The drug which had an inhibitory effect in angiogenesis for rabbit corneal neovascularization is the only antiangiogenesis agent that is currently ready for human efficacy trials. We investigated the inhibitory effect of thalidomide using preretinal neovascularization model. Though there was no significant difference, it tended to have an inhibitory effect on retinal neovascularization in rats.
We investigated the roles of growth factors and cytokines in pre- and sub- retinal neovascularization using rat models. We found a-FGF,b-FGF and VEGF had significant role in the development of above neovascularizations.
We also attempted to improve the surgical result or clinical knowledge of diseases which develop the preretinal and/or subretinal neovascularization : retinopathy of prematurity, diabetes, age-related macular degeneration.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Saito Y.et al.: "Macular Change as a Complication of successful〜" Am J Ophthalmol. 122. 299-308 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y.et al.: "Leus changes at rapid tightening of netabulic〜" Lancet. 347. 1764- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y.et al.: "Experithental miclel of preretinal neovascin larization〜" Cur Eye Res. 16. 26-33 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Watanabe et, al: "Massive proliferation of conjuactival fissue,after" Arch Ophthal. 115. 278-279 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 斉藤 喜博: "Retinal Prgment Epithelial Lesions associated with〜" Retinal. (印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsujikawa: "Chorioretinal damage caased by the exision of〜" Am J Ophthalunol. (印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 斉藤 喜博: "眼内細胞増殖の実験モデル" メジカルビュー, 10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 生野 恭司, 斉藤 喜博: "糖尿病網膜症と血液網膜6冊" メジカルビュー, 8 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y,et al.: "Macular change as a complication of successful cryotherapy for retinopathy of prematurity." Am J Ophthalmol. 122. 299-308 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y,et al.: "Lens changes at rapid tightening of metabolic control in diabetes." Lancet. 347. 1764 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y, et al.: "Experimental model of preretinal neovascularization by laser induced venous thrombosis in rats." Cur Eye Res. 16. 26-33 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Watanabe H,Tsukamoto Y,Saito Y,et al.: "Massive proliferation of conjunctival tissue after cryotherapy for retinopathy of prematurity." Arch Ophthalmol.115. 278-279 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsujikawa M,Saito Y,et al.: "Differentiating full thickness macular holes from impending macular holes and macular pseudoholes." Br J Ophthalmol. 81. 117-122 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsujikawa M,Saito Y,et al.: "Secondary vitrectomy for the treatment of macular holes occurring after vitrectomy." Ophthal Surg Lasers. 28. 336-337 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Lewis JM,Park I,Ohji M,Saito Y,et al.: "Diamond-dusted silicon cannula for membrane separation during vitreous surgery." Am J Ophthalmol. 124. 552-554 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sugimoto S,Furukawa A,Hatsukawa Y,Yanagihara K,Saito Y.: "Weak association between retinopathy of prematuriry and neurological disorders in childhood." Jpn J Ophthalmol. 42 : (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y,et al.: "Retinal Pigment Epithelial Lesions Associated with Choroidal Ischemia in Preeclampsia." Retina. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsujikawa M,Sawa M,Motokura M,Tsujikawa K,Ohji M,Saito Y,et al.: "Chorioretinal damage caused by the excision of choroidal neovascularization." Am J Ophthalmol. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohji, M., Fujikado, T., Saito, Y., et al.: "Foveal translocation : A comparison of two techniques." Seminars in Ophthalmol. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujikado T,Ohji M,Saito Y,et al.: "Visual function after foveal translocation with scleral shortening in patients with myopic neovascular maculopathy" Am J Ophthalmol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y.: "Macular change after coagulation therapy for retinopathy of prematurity." Jpn J Ophthalmol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tatebayashi M,Saito Y,et al: "Experimental model of preretinal neovascularization by laser-induced venous occlusion in albino rats." ARVO (April 21-26,1996).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsujikawa M,Saito, Y,et al.: "The inhibitory effect of thalidomide for experimental preretijnal neovascularization by laser induced venous occlusion in rats." ARVO (April 21 26,1996).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y,Et al.: "Macular pigmentary change as a complication of successful cryotherapy for retinopathy odf prematurity." ARVO (April 21-26,1996).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sawa M,Kamei M,Tsujikawa M,Ohji M,Saito, Y,et al.: "Outer blood-retinal barrior reconstruction after surgical removal of choroidal neovascularization." ARVO (May 11 16,1997).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohji M,Saito Y,et al.: "Removal of subretinal choroidal neovascular membranes without gas tamponade." ARVO (May 11-16,1997).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakabayashi M,Fujikado T,Tsujikawa M,Ohji M,Saito Y,et al.: "Fixation patterns of macular hole after successful vitreous surgery." ARVO (May 11-16,1997).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito, Y,et al.: "A lens change and related symptoms during rapid tightening of metabolic control in diabetes." ARVO (May 11-16,1997).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito Y.et al: "Macular Change as a conptication of successful〜" An J Ophthal. 122. 299-308 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito Y.et al: "Lens Changes at rapid tightening of metaholic" Cancet. 347. 1764 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito Y.et al: "Experimental model of peretinal neovascularization" Cav Eye Res. 16. 26-33 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Watanabe et al: "Massive prolitevative of coujunctival tissue after" Arch Ophthal. 115. 278-279 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito Y.et al: "Retinal Pigmant Egithelial lesion associated with〜" Retina. 印刷中 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsujikawa: "Chorioretinol damuge caused by the exision of" Aun J Ophthalmol. 印刷中 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 斉藤喜博: "眼内細胞増殖の実験モデル" メジカルビュー, 10 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 生野恭司、 斉藤喜博: "糖尿病網膜症と血液網膜柵" メジカルビュー, 8 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito Y.et al.: "Lens changes at rapid fightening of metabolic control〜" The Lancet. 347. 1764- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saito Y.et al: "Macular Change as a complication of successful chyotherapy〜" American J of Ophthalmology. 122. 299-308 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saito Y.et al: "Experimental model of prevetinal neovascularization〜" Current Eye Research. (印刷中).

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsujikawa,Saito et al: "Differentiation of full-thickness macular holes〜" British Journal of Ophthalmology. 81. 117-122 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsujikaw M.Saito et al.: "Secondary vitrecfony for the treatment of macular〜" Ophthalmic Surgery and lasers. (印刷中).

    • Related Report
      1996 Annual Research Report
  • [Publications] 斉藤 喜博: "眼科New Insght第7巻「眼内細胞増殖」" メジカルビュー社, 10(112-121) (1996)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi