| Project/Area Number |
07557320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Laboratory medicine
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
KAMBE Masayuki Hiroshima University, School of Medicine, Professor, 医学部, 教授 (70034139)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Toshiki Hiroshima University, Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (00253104)
MORISHITA Kazuhiko Hiroshima University, School of Medicine, Assistant Professor, 医学部, 講師 (60239647)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | P0.1 / RESPIRATORY CENTER / RESPIRATORY CONTROL / AIRWAY OCCLUSION PRESSURE / 呼吸反射テスト / 機械的受容器 / 化学受容器 / 呼吸中枢機能 / 気道抵抗 / 胸郭抵抗 / 呼気NOガス / 睡眠時無呼吸症候群 |
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| Research Abstract |
We developed the new automatic machine to measure the respiratory functions which is in brain stem.
This machine is composed two manometers to measure the airway occlusion pressure and the air flow of mouth included computer tips and one recorder.
The principle of this machine is due to the inspiratory phase of breath is activated by N.Vagus from the respiratory center.
We know already the respiratory center controls the breath based on the change of inter pressure of chest wall which can moves the lungs.
By using of this new machine, we could analyze airway occlusion pressure duaring full inspiratory phase, P<@D20.1@>D2 (airway occlusion pressure at 0.1 secounds) and breath curves. So, we could analyze not only P<@D20.1@>D2 but the switch mechanism between inhale and exhale of breath among patients with some respiratory diseases. Specially, we could have an interesting result P<@D20.1@>D2 of non-attached bronchial asthma cases (28.0(]SY.+-。[)7.5mmH<@D22@>D2o) is more than P<@D20.1@>D2 of normal cases (17.6(]SY.+-。[)4.7mmH<@D22@>D2o). Although we must study the mechanisms of increasing of P<@D20.1@>D2 of non-attached bronchial asthma cases, we believe this machine is useful for patients with respiratory diseases.
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