| Project/Area Number |
07557323
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokai University School of Medicine |
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Principal Investigator |
SHINOHARA Yukito Tokai University School of Medicine, Neurology, Professor, 医学部, 教授 (60051504)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yoshitosi Central Laboratory of Hitach, Ltd.Chef technician, 中央研究所, 主任研究員
KAWAGUCHI Fumio Central Laboratory of Hitach, Ltd.Chef researcher, 中央研究所, 主任研究員
HAIDA Munetaka Tokai University School of Medicine, Neurology, Associate Professor, 医学部, 講師 (20208408)
IZUMI Yoshio Tokai University School of Medicine, Neurology, Associate Professor, 医学部, 講師 (30151426)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1996: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | optical CT / near infrared light / hemoglobin / oxygen saturation / ischemia / brain / 半導体レーザー / 脳血流 / 脳代謝 |
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| Research Abstract |
We have been making an effort to create rat brain hemoglobin oxygen saturation image by using two wave length of near infra-red light (NIR), which gives only the ratio such as oxygen saturation. This study employed three wave length of NIR,and obtained total hemoglobin and its saturation images. In first year, we applied this method to a hypoxic brain model to evaluate usefulness of this method, and successively obtained an increase of deoxy hemoglobin and decrease of oxyhemoglobin at lower limit of FIO_2 (7.5% O_2). Second year, we applied this method to an infraction model of rat brain, and obtained hemoglobin images which clearly showed the infarcted legion. These results suggest an usefulness of the optical imaging method to detect oxygenation state of brain non invasively.
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