| Co-Investigator(Kenkyū-buntansha) |
FURUYA Seiichi Kyoto Prefectural University of Medicine, Faculty of Medicine, Lecturer, 医学部, 助手 (10271173)
UMEDA Masahiro Meiji College of Oriental Medicine, Faculty of Acupuncture, Lecturer, 鍼灸学部, 講師 (60223608)
NARUSE Shoji Kyoto Prefectural University of Medicine, Faculty of Medicine, Lecturer, 医学部, 講師 (50106407)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
We have designed to develop the dual magnetic resonance microscopic imaging (MRMI) method for liquid and solid tissue in biological systems, by which tissues consisting of both liquid and solid substances could be visualized microscopically as a level of micrometer.
As the first step, we have developed the MR hardware, in which the most important factor is the requirement of strong magnetic field and the strong gradient coil without eddy current problems. In the first year, the specification of gradient coil was decided and the computer systems for controlling of measurements was introduced during a short period after late decision of this grant. In the second year, we aimed to complete the total system as the following steps and to do the experiment in animals. At first, the extremely strong gradient coil with 24 mm in diameter is designed to be inserted to the NMR device for animal use (Varian, Unity INOVA 300SWB,300MHz, 15cm diameter) which was installed last September. However, we f
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ound the fatal trouble in the NMR device itself and we are now waiting for being repaired. This trouble is completely responsible to the manufacturer, and we have no choice but to change our schedule of this research. Unwillingly, we tried to develop the pulse sequence for data acquisition on another NMR device (Brucker AMX300WB). Using this system, we can confirm that microscopic MR image in a micrometer order is possibly obtained from the liquid phantom. However, we are now trying to apply this method to the solid system, and not yet get the image.
The reason of delayd schedule is completely due to the incompleteness of main NMR device which is responsible to the manufacturer, Varian (Palo Alto, USA). The NMR device is still under reconstruction and readjustment. After completing this procedure, we will try to apply the pulse sequence to phantom and rat. Although we could not get a good result due to the unexpected technical problem, this method is extremely important because of getting high resolution image of both liquid and solid systems in alive animals. Also this method will be able to apply to the clinical field, and therefore it is promising in the application in both experimental and clinical medicine. In this sense, further research should be continued. Less
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