| Project/Area Number |
07558107
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tohoku University |
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Principal Investigator |
YANAI Kazuhiko Tohoku University School of medicine, Associate Professor, 医学部, 助教授 (50192787)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Keiji Fuji Photo Film, Head Scientist, 企画リーダー
IWATA Ren Tohoku University, Cyclotron and RI Center, Professor, サイクロトロンRIセンター, 助教授 (60143038)
ISHII Keizo Tohoku University, Faculty of Technology, Professor, 工学部, 教授 (00134065)
ITOH Masatoshi Tohoku University, Cyclotron and RI Center, Professor, サイクロトロンRIセンター, 教授 (00125501)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1996: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1995: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Keywords | Brain function / PET / autoradiography / Histamine / HistamineH,Receptor / Alzheimer disease / antihistamines / human brain / ノックアウトマウス / ヒスタミンH-1受容体 / 3次元PET / ポジトロン / ヒスタミン受容体 / イメージングプレート / オートラジオグラフィー |
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| Research Abstract |
Three-Dimensional Aquision Positron Emission Tomography (3D-PET) was developed at Tohoku University Cyclotron Radioisotope Center. Our 3-D PET system is characterized by the reconstruction of images by a supercomputer at Tohoku University Computer Center. With this methods, it takes about 5-10 min to reconstruct the images obtained with 3-D PET.The images obtained by [^<18>F] fluoro-dopa and [^<11>C] doxepin using 2-D PET and 3-D PET were compared. Clear images could be visualized using only 3-D PET,but not by conventinal 2-D PET.The differnce is mainly due to low dose of administered radioactivity and shorter scanning time. 3-D PET is more powerful the 2-D PET in activation study because the sensitivity of 3-D PET is superior to that of 2-D PET.The application of 3-D PET to activation study is now in progress. We also developed a double-labeled receptor autoradiography using [^<11>C] labeled ligands and [^3H] labeled ligands. Using this new techniques, two different receptors were visualized in a single section.
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