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Evaluation of Newly Designed Adsorbents for Selective Removal of Glycosylated LDL

Research Project

Project/Area Number 07558119
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section試験
Research Field Biomedical engineering/Biological material science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

MIYAURA Norio  Hokkaido Univ., Fac.of Eng., Pro., 工学部, 教授 (10002049)

Co-Investigator(Kenkyū-buntansha) KAKUCHI Toyoji  Hokkaido Univ., Graduate School of Enviromental Earth Science., Pro., 大学院・地球環境科学研究科, 助教授 (80113538)
ISHIYAMA Tatsuo  Hokkaido Univ., Fac.of Eng., Pro., 工学部, 助教授 (00232348)
MURABAYASHI Syun  Hokkaido Univ., Fac.of Eng., Pro., 工学部, 助教授 (30200306)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 1996: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1995: ¥8,600,000 (Direct Cost: ¥8,600,000)
Keywordsvascular impairment / adsorbent / stirene boronic acid / plasma apheresis / diabetic oatients / human plasma / dual ligands / glc-LDL / 血管障害 / 医療用高分子 / 糖化アルブミン
Research Abstract

Secondary vascular impairments are frequently observed among diabetic patients. It is considered that the reason of the impairments is the existence of glycosylated compounds, especially glycosylated LDL (glc-LDL). Newly designed adsorbents were synthesized and prepared aiming for a selective removal of glc-LDL from human plasma. The polymers had two functional groups for the adsorption of glc-LDL,one is boronic acid for a glycosylated sites of glc-LDL,the other is acrylic acid (AA) for a positive charge of apoprotein. The adsorbents were evaluated in terms of glc-LDL adsorption efficiently in human plasma, and exhibited different selectivity depending on the polymer compositions. The AA compositions from 50 to 90% revealed the high selectivity for glc-LDL.The selective adsorptions of glc-LDL were not inhibited in human plasma. These results suggested that the adsorbents would be promising materials for glc-LDL apheresis.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] T. Sato: "Regio-and stereospecificity in cationic cyclopolymerization of 1,2'5,6-dianhydro-3,4-di-O-methyl-D-mannitol and L-iditol and the synthesis of poly [(1-6)-2,5-glucitol]" Macromolecules,. 28. 5643-5648 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Ishiyama: "Palladium-Catalyzed Cross-Coupling Reaction of (Alkoxy) diboron with Haloarenes : A direct Procedure for Arylboronic Esters" J. Org. Chem.,. 60. 7508-7510 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Ishiyama,: "Platinum(0)-Catalyzed Diboration of Alkynes with Tetra (alkoxo) diborons : An Efficient and Convenient Approach to cis-Bis (boryl) alkenes," Organometallics. 15. 713-720 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西出拓司: "血中糖化LDLの除去を目的とした吸着剤の開発" 人工臓器、. 25. 156-161 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Ishiyama: "A Synthesis of Arylboronates via the Palladium-Catalyzed Cross-Coupling Reaction of Tetra (alkoxy) diboron with Aryl Triflates," Tetrahedron Lett.,. 38(発表予定). (1977)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Miyaura: "Current Topics in the Chemistry of Boron, Royal Society of Chemistry," Synthesis of Arylboronates via Palladium-Catalyzed Cross-Coupling Reaction of Alkoxydiboron with Aryl Halides or Triflates., (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Sato, T.Hatakeyama, S.Umeda, K.Yokota, T.Kakuchi: "Regio- and stereospecificity in cationic cyclopolymerization of 1,2'5,6-dianhydro-3,4-di-O-methyl-D-mannitol and L-iditol and the synthesis of poly [(1-6)-2,5-anhydro-3,4-di-O-methyl-D-glucitol]" Macromolecules. 28. 5643-5648 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ishiyama, N.Matsuda, M.Murata, A.Suzuki, and N.Miyaura: "Palladium-Catalyzed Cross-Coupling Reaction of (Alkoxy) diboron with Haloarenes : A direct Procedure for Arylboronic Esters" J.Org.Chem.60. 7508-7510 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ishiyama, N.Matsuda, M.Murata, F.Ozawa, A.Suzuki, N.Miyaura: "Platinum (0) -Catalyzed Diboration of Alkynes with Tetra (alkoxo) diborons : An Efficient and Convenient Approach to cis-Bis (boryl) alkenes" Organometallics. 15. 713-720 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nishide, S.Murabayashi, T.Yuta, Miyaura, N.T.Kakuchi, S.Nakaji, K.Oka, A.Sueoka, Y.Abe: "Evaluation of Newly Designed Adsorbents for Selective Removal of Glycosylated LDL" Jpn J Artif.Organs. 25. 156-161 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ishiyama, Y.Itoh, T.Kitano, N.Miyaura: "Synthesis of Arylboronates via the Palladium (0) -Catalyzed Cross-Coupling Reaction of Tetra (alkoxo) diborons with Aryl Triflates" Tetrahedron Lett.38(in press). (1977)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ishiyama and N.Miyaura: "Synthesis of Arylboronates via Palladium-Catalyzed Cross-Coupling Reaction of Alkoxydiboron with Aryl Halides or Triflates" Current Topics in the Chemistry of Boron, Royal Society of Chemistry. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Ishiyama: "Palladium-Catalyzed Cross-Coupling Reaction of (Alkoxy) diboron with Haloarenes : A direct Procedure for Arylboronic Esters," J. Org. Chem.,. 60. 7508-7510 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T. Ishiyama: "Platinum (O)-Catalyzed Diboration of Alkynes with Tetra (alkoxo) diborons : An Efficient and Convenient Approach to cis-Bis (boryl) alkenes," Organometallics,. 15. 713-720 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 西山拓司: "血中糖化LDLの除去を目的とした吸着剤の開発" 人工臓器、. 25. 156-161 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T. Ishiyama: "A Synthesis of Arylboronates via the Palladium-Catalyzed Cross-Coupling Reaction of Tetra (alkoxy) diboron with Aryl Triflates," Tetrahedron Lett.,. 38(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] N. Miyaura: "Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds," Chem. Res.,. 95. 2457-2483 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 村林俊、: "血中糖化LDLの除去を目的とした吸着材の開発" 人工臓器. 125(発表予定). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 覚知豊次: "Regio-and stereospecificity in cationic cyclopolymerization of 1,2'5,6-dianhydro-3,4-di-O-methyl-D-mannitol and L-iditol" Macromolecules,. 28. 5643-5648 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Ishiyama,: "Palladium-Catalyzed Cross-Coupling Reaction of (Alkoxy)diboron with Haloarenes: A direct Procedure for Arylboronic Esters," J. Org. Chem.,. 60. 7508-7510 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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