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Evaluation of Coronary Vasoregulation Through Controlling Regional Myocardial Flow

Research Project

Project/Area Number 07558134
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section試験
Research Field Biomedical engineering/Biological material science
Research InstitutionKawasaki College of Allied Health Professions

Principal Investigator

MATSUMOTO Takeshi  Kawasaki College of Allied Health Professions, Dept. of Applied Medical Engineering, Assistant Professor, 医用電子技術科, 講師 (30249560)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Takehiko  Kyraray Co. Medical Research & Development, Chief Researcher, 開発室, 主任研究員
OGASAWARA Yasuo  Kawasaki Medical School, Dept. of Medical Engineering and Systems Cardiology, As, 医学部, 講師 (10152365)
KAJIYA Fumihiko  Kawasaki Medical School, Dept. of Medical Engineering and Systems Cardiology, Pr, 医学部, 教授 (70029114)
MOCHIZUKI Seiichi  Kawasaki College of Allied Health Professions, Dept. of Applied Medical Engineer, 医用電子技術科, 講師 (60259596)
GOTO Masami  Kawasaki College of Allied Health Professions, Dept. of Applied Medical Engineer, 医用電子技術科, 助教授 (50148699)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscoronary vasoregulation / regional myocardial perfusion / nitric oxide / shear flow stress / molecular flow marker / flow heterogeneity / 磁性流体 / 微細NO電極
Research Abstract

The intrinsic pattern of myocardial perfusion is determined by coronary vascular tone. Since the most principal sites of coronary vascular tone are the arterioles, the evaluation of coronary circulation on a microscopic level is indispensable to understand the coronary vasoregulatory function. In this study, we applied a newly developed nitric oxide (NO) microsensor to measure the concentration of vascular tissue NO,which plays an essential role in regional myocardial flow regulation. Furthermore, we visualized the spatial pattern of within-layr myocardial perfusion by digital-radiography combined with a molecular deposition technique. The analysis of myocardial perfusion pattern gives valuable information on the coronary vasoregulation because its characteristics of hierarchical structure are reflected in myocardial perfusion pattern. The experimental results were summarized as follows.
The No sensor was inserted into the vascular media of the isolated canine femoral artery, perfused w … More ith a Krebs-Henseleit solution. NO concentration in the vascular media increased linearly with perfusion flow rate (flow shear stress on the vascular wall) and also with administration of a substrate of NO synthase, L-arginine. NO production, i. e., measured current was attenuated by perfusing a solution containing an inhibitor of NO synthase, N^<omega>-nitro-L-arginine. It is thus shown that the new NO sensor has satisfactory performance for a selective measurement of NO in the vascular media.
Microregional myocardial flows are more uniform and continuous at high O_2 consuming or low O_2 supply states. There were transmural differences in a regional flow correlation in the left ventricular myocardium, which may be due to the higher O_2 consumption in the subendocardium. Since the regional flow correlation in the subepicardium was increased to a similar level observed in the subendocardium during hypoxia, the subepicardium will allow heterogeneous flow patterns in normoxia, but not anymore in hypoxia in comparison with the subendocardium. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report

Research Products

(24 results)

All Other

All Publications

  • [Publications] T.Matsumoto H.Tachibana et al.: "Regional Blood Flow Heterogeneity Within the Rabbit Lett Ventricle During the Normoxic and Hypoxic States." Microcirculation Annual. 11. 63-64 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto H.Tachibana et al.: "Blood Flow Distribution in Endocardium and Epicardium of Left Ventricle During Normoxia and Hypoxia Evaluated by a Molecular Flow Tracer" Circulation. 92(Suppl I). 133 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Mochizuki M.Goto et al: "Direct Measurement of Nitric Oxide in Arterial Wall Using Newly Developed Nitric Oxide Microsensor" Medical Engineering-Applications,Basis and Communication. 8. 18-23 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto M.Goto et al: "Microheterogeneity of Myocardial Blood Flow in Rabbit Heart During the Normoxic and Hypoxic States." Am.J.Physiol. 270. H435-H441 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Ebata T.Matsumoto et al: "Micro-regional Blood Flow Pattern Within the Rabbit Right Ventricular Myocardium" Microcirculation Annual. 12. 115-116 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto J.Ebata et al: "Spatial Fluctuation of Regional Myocardial Blood Flows" Methods of Information in Medicine. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto, H.Tashibana, M.Goto, J.Ebata, Y.Ogasawara, K.Tsumjioka, F.Kajiya: ""Regional Blood Flow Heterogeneity within the Rabbit Left Ventricle During the Normoxic and Hypoxic States, "" Microcirculation Annual. 11. 63-64 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Mochizuki, M.Goto, J.Ebata, C.Tokuda, T.Matsumoto, Y.Ogasawara and K.Tsujioka: ""Direct Nitric Oxide Measurement in Arterial Wall by Nitric Oxide Sensing Electrode, "" Circulation. 92 (8) (Suppl. I). 108 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto, H.Tachibana, M.Goto, Y.Ogasawara, C.Tokuda, K.Morita, S.Mochizuki, F.Kajiya: ""Blood Flow Distribution in Endocardium and Epicardium of Left Ventricle During Normoxia and Hypoxia Evaluated by a Molecular Flow Tracer, "" Circulation. 92 (8) (Suppl. I). 133 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Ohta, Y.Ogasawara, T.Matsumoto, T.Okamoto, A.Kimura, T.Yada, O.Hiramatsu, H.Tachibana, S.Mochizuki, M.Goto, K.Tsujioka, F.Kajiya: ""Analysis of Coronary Haemodynamics by Coronary Circulation Model with Three Layr Myocardium, "" IEEE Computers in Cardiology 1995. 673-676 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto, M.Goto, H.Tachibana, Y.Ogasawara, K.Tsujioka, and F.Kajiya: ""Microheterogeneity of Myocardial Blood Flow in Rabbit Heart During the Normoxic and Hypoxic States, "" Am. J.Physiol.270. H435-H441 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Ebata, T.Matsumoto, H.Tachibana, M.Goto, Y.Ogasawara, F.Kajiya: ""Micro-regional Blood Flow Pattern Within the Rabbit Right Ventricular Myocardium, "" Microcirculation Annual. 12. 115-116 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Mochizuki, M.Goto, K.Hirano, Y.Fukuhiro, and F.Kajiya: ""Direct Measurement of Nitric Oxide in Arterial Wall Using Newly Developed Nitric Oxide Microsensor, "" Medical Engineering-Applications, Basic and Communication. 8 (4). 18-23 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Ebata, H.Tachibana, M.Goto, K.Tsujioka, and F.Kajiya: ""Myocardial Blood flows in Micro-regions of the Rabbit Right Ventricle Evaluated by a Molecular Flow Tracer-In Reference With The Left Ventricle-, "" J.Cardiovas. Diag. Proc.13. 304 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Ebata, K.Tsujioka, Y.Ogasawara, and F.Kajiya: ""Spetial Fluctuation of Regional Myocardial Blood Flows, "" Methods of Information in Medicine. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Matsumoto, H.Tachibana. et al.: "Regional Blood Flow Heterogeneity within the Rabbit Left Ventricle During the Normoxic and Hypoxic States." Microcirculation Annual. 11. 63-64 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Matsumoto, H.Tachibana, et al.: "Blood Flow Distribution in Endocardium and Epicardium of Left Ventricle During Normoxia and Hypoxia Evaluated by a Molecular Flow Tracer." Circulation (Suppl.I). 92・8. 133 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Mochizuki, M.Goto, et al.: "Direct Measurement of Nitric Oxide in Arterial Wall Using Newly Developed Nitric Oxide Microsensor." Medical Engineering-Applications, Basis and Communication. 8・4. 18-23 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Matsumoto, M.Goto, et al.: "Microheterogeneity of Myocardial Blood Flow in Rabbit Heart During the Normoxic and Hypoxic States." Am.J.Physiol. 270. H435-H441 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Ebata, T.Matsumoto, et al.: "Micro-regional Blood Flow Pattern Within the Rabbit Right Ventricular Myocardium." Microcirculation Annual. 12. 115-116 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Matsumoto, J.Ebata et al.: "Spatial Fluctuation of Regional Myocardial Blood Flows." Methods of Information in Medicine. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 梶谷文彦,矢田豊隆,松本健志: "心内膜側微小循環の特徴" 循環器科. 38. 142-150 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 望月精一 他: "微細一酸化窒素電極による臓器内一酸化窒素の計測" 医科器械学. 66. 24-28 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Seiichi Mochizuki,et al.: "Direct Nitric Oxide Measurement in Arterial Wall by Nitric Oxide Sensing Electrode" Circulation(Suppl.). 92. I-108 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-03-31   Modified: 2016-04-21  

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