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Development and utilization of recombinant inbred strains of mice.

Research Project

Project/Area Number 07558239
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Laboratory animal science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NISHIMURA Masahiko  Hamamatsu University School of Medicine Faculty of Medicine, Associate professor, 医学部, 助教授 (20073661)

Co-Investigator(Kenkyū-buntansha) MORI Masayuki  Hamamatsu University School of Medicine, Research associate, 医学部, 助手 (60273190)
OHSUGI Naohiro  Japan SLC,Inc., Head, 品質管理部, 主任研究員
HIAI Hiroshi  Kyoto University, Faculty of Medicine, Professor, 医学部, 教授 (10073131)
浅井 秀一  日本エスエルシー(株), 春野支所, 支所長
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsrecombinant indbred strains / SMXA / SM / J / A / pulmonary adenoma / strain distribution patterns / quantitative trait loci / QTL解析 / 遺伝解析 / 血液生化学値 / インスリン抵抗性 / 血清脂質 / 系統差 / 体重 / 血液性状 / 肺腫瘍 / DNAマーカー / Recombinant Inbred strains / SDP / QTL / マイクロサテライト / マウス
Research Abstract

SMXA recombinant in bred (RI) strains consisting of 26 substrains were established between SM/J and A/J.Genotypes and some characteristics were elucidated as follows.
1. We searched polynorphism between progenitor strains and determined their strain distribution patterns (SDPs) among 26 RI strains.
As a result SDPs of the RI strains were defined by total 400 genetic markers, including 187 microsatellite markers, 2 coat colors, 14 biochemical and 7 immunological markers, 1 biological marker, and 187RLGS (restriction landmark genomic distribution scanning) markers.
2. We first examined the incidence of urethan-induced pulmonary adenomas (PAs) in the RI strains. Of these strains, the SMXA24 was highly resistant to PA despite having A/J-derived alleles at all four PA sensitive genes. Quantitative trait analysis of the backcross generation revealed a new resistance gene named PAR3 on chromosome 12.
3. We examined plasma lipids (triglyceride, total cholesterol, phospholipid) and insulin level at 10 weeks of age in the RI strains. Two strains (SMXA5 and 9) showed obese-hyperglycemia, insulin resistance, glucose intolerance, elevated plasma lipids and hyperinsulinemia.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Nishimura M.: "The SMXA:a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile." Mamm.Genome. 6. 850-857 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Niwa-Kawakita M.: "Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia." Genomics. 29. 755-759 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sudo T.: "Identification and minisatellite linkage analysis of SMXA recombinant inbred strain of mice by DNA fingerprinting." Exp.Anim.44. 87-93 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka S.: "Strain difference of the adrenal cortex between A/J and SM/J mice,progentitors of SMXA recombinant inbred group." Exp.Anim.44. 127-130 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishih.A.: "Differential responses of SM/J and A/J mice to experimental Angiostrongylus costaricensis infection." International Journal for Parasitology. 27. 1411-1414 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohtake T.: "Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-induced nephropathy." J.Lab.Clin.Med.129. 81-88 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Pataer A.: "Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred strains." Cancer Research. 57. 2904-2908 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 日合 弘: "肺癌の感受性遺伝子" Molecular Medicine. 34. 676-681 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mori M.: "Detailed genetic profile of the SMXA recombinant inbred mouse strain revealedwith restriction landmark genomic scanning." Mamm.Genome. (in print).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nishimurs, M. : The SMXA: "a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile" Mamm.Genome. 6. 850-857 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Niwa-Kawakita M.: "Cloning and gene mapping of the mouse homologue of the CBFA2TI gene associated with human acute myeloid leukemia." Genomics. 29. 755-759 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sudo, T.: "Idenification and minisatellite linkage analysis of SMXA recombinant inbred strain of mice by DNA fingerprinting." EXP.Anim.44. 87-93 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, S.: "Strain difference of the adrenal cortex between A/J and SM/J mice, progentitors of SMXA recombinant inbred group." EXP.Anim.44. 127-130 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishih, A: "Differential responses of SM/J and A/J mice to experimental Angiostrongylus costaricensis infection." International Journal for Parasitology. 27. 1411-1414 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohtake, T.: "Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-induced nephropathy." J.Lab.Clin.Med.129. 81-88 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Pataer, A.: "Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred strains." Cancer Research. 57. 2904-2908 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mori, M.: "Detailed genetic profile of the SMXA recombinant inbred mouse strain revealed with restriction landmark genomic scanning." Mamm.Genome.(in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Pataer A: "Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred strains mice." Cancer Res.57. 2904-2908 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishii A.: "Differential responses of SM/J and A/J mice,progenitor strains of recombinant inbred strain SMXA,to experimental Angiostrongylu constaricensis infection." International Journal For Parasitology. 27. 1411-1414 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohtake T.: "Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-inbred nephropathy." J.Lab.Med.129. 81-88 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 日合 弘: "肺癌の感受性遺伝子" Molecular Medicine. 34. 675-681 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mori M.: "Detailed genetic profile of the SMXA recombinant inbred mouse strain revealed with restriction landmark genomic scanning." Mamm.Genome. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishimura M.: "The SMXA : a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile." Mammalian Genome. 6. 850-857 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka S.: "Strain difference of the adrenal cortex between A/J and SM/J Mice,progenltors of SMXA recombinant inbred group." Exp.Anim.44. 127-130 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohtake T.: "Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-induced nephropathy." J.Lab.Chin.Med.129. 81-88 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nose M.: "Arteritis in a novel congenic strain of mice derived from MRL/1pr lupus mice." American Journal of Pathology.149. 1763-1769 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kamoto T.: "A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas." Jpn.J.Cancer Res.87. 401-404 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Abujiang P.: "The origin of the SL family mice." Lab.Anim.Sci.46. 410-417 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsubata R.: "Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice : A single gene model for siogren syndrome." Eur.J.Immunol.26. 2742-2748 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiai H.: "Genetic predisposition to lymphomas in mice." Pathol.Intern.46. 707-718 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishimura,M.: "The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile." Mammalian Genome. 6. 850-857 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sudo,T.: "Identification and minisatellite linkage analysis of SMXA recombinant inbred strains of mice by DNA fingerprinting." Exp. Anim.44. 87-93 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka,S.: "Strain difference of the adrenal cortex between A/J and SM/J mice, progenitors of SMXA recombinant inbred group." Exp. Anim.44. 127-130 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Niwa-Kawakita,M.: "Cloning and gene mapping of mouse homologue of the CBFA2Tl gene associated with human acute myeloid leukemia." Genomics.29. 755-759 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshimura,N.: "Histochemical localization of copper in various organs of brindled mice after copper therapy." Pathology International. 45. 10-18 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ahmed,S.S.: "Fc receptors in liver sinusoidal endothelial cells in NZB/W Fl lupus mice: A histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody(2.4G2)." Hepatology. 22. 316-324 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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