| Project/Area Number |
07558292
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
神経・脳内生理学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHINODA Yoshikazu Tokyo Medical and Dental University, Department of Physiology, Professor, 医学部, 教授 (60010104)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIHARA Izumi Tokyo Medical and Dental University, Department of Physiology, Lecturer, 医学部, 講師 (60187656)
桑山 隆夫 日本光電工業(株), 光電エンジニアリング部門, 専務取締役
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Intracellular recording / brain / electrical stimulator / neurophysiology / コンピューター / データファイル / 刺激装置 / ディジタル |
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| Research Abstract |
This study was aimed at developing a computer-assisted recording system for electrophysiological data in in vivo experiments of the mammalian central nervous system. In an electrophysiological experiment of the mammalian central nervous system, we stimulate a certain structure, record electrical potentials from inside a neuron and analyze the neural connections between them. Intracellular recording is very difficult and it is much harder to keep recording from a cell for a long time. To record as much data as possible for a limited period, many researchers use a data recorder to acquire the data. This is convenient for off-line data analysis. On the other hand, we also have to record various parameters which are used for stimulation and recording. These values are usually written down on a notebook or recorded on a voice channel on a tape. For later analysis of the data on a computer, these parameters were typed from a key board. It takes a long time for acquiring the data into the computer and also typing the necessary parameters. Therefore, it is desirable that we will develop a new recording system for neurophysiological experiments which wll speed up recording and analytical procedures. There are several commercially available computer-assisted system for neurophysiological data acquisition and analysis. However, these systems are only useful for patch clamp experiments or unit recording in chronic electrophysiological experiments because of their slow data acquisition capability. We made a new stimulator which could tell the computer all necessary stimulus parameters by digital signals. Computer software was developed to acquire data, and display and store data simultaneously at high frequencies. With this new stimulating and recording systems, we speed up the recording procedure and get more data for a limited period. Furthermore, it is much easier and faster to analyze data on a computer.
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