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Bioinorganic chemical studies on behavior of selenium and other metals by the use of multielemental analysis.

Research Project

Project/Area Number 07640742
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionKanazawa University

Principal Investigator

AMANO Ryohei  Kanazawa University Faculty of Medicine, Professor, 医学部, 教授 (30111769)

Co-Investigator(Kenkyū-buntansha) ENOMOTO Shuichi  Kanazawa University Institute of Physical & Chemical Research, Researcher., 核化学研究室, 基礎科学特別研究員 (10271553)
OISHI Shigeo  Kanazawa University Faculty of Medicine, Asistant., 医学部, 助手 (30272983)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsmultitracer experiment / neutron activation analysis / trace element, V,Mn, Rb / regional cerebral tracer uptake / regional cerebral concentration / brain function / age effect / mouse experiment / マルチトレーサ法 / 中性子放射化分析法 / 脳機能 / ラジオアイソトープ / セレン / バナジウム / 骨集積
Research Abstract

This study was undertaken in order to acquire better understanding of the biobehavior of selenium and other trace metals by the techniques of multitracer and instrumental neutron activation analysis. The followings were found.
1). The radioactive multitracer technique, which was established at RIKEN,enables simultaneous tracing of a number of elements in a variety of bio-systems and an accurate comparison of their biobehavior. In this work, the multitracer technique was thus shown to be useful for comparative studies of behavior of trace elements in living bodies.
2). We find new facts using the radioactive multitracer technique. (a) V is a bone-seeking element probably playing an role in bone metabolism. (b) Rubidium uptake rates for all soft tissues of mice housed under a 10% O_2 atmosphere were found to be higher than those of the tissues of mice housed under the other three O_2 atmospheres (20%, 80%, and 100%), but no difference was observed for the other elements (Sc, Mn, Fe, Co, Se, etc.) under any of O_2 the atmospheres. (c) Regional cerebral uptake behaviors of Mn, Fe, Zn and Se trace elements were determined in normal C57BL/6N mice, by using a quadruple radioactive tracers. In all regions the uptake rates were found in the following order ; Zn > Mn > Fe >Se.
3). Form the technique of instrumental neutron activation analysis for small amount of regional samples. No difference in regional concentration was found in the brain of young and aged mice for the elements, Na, Mg, Cl, K,Rb and Br. On the other hand, significant differences were found for the element, Mn, in all regions of the brain of young and aged mice.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 天野 良平、他: "Bone uptake of vanadium in mice : Simultaneous tracing of V,Se,Sr,Y,Zr,Ru and Rh using a radioactive multitracer" J.Trace Elements Med.Biol.10(3). 145-148 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 天野 良平、他: "Biodistribution of trace elements in normal,Al-overloaded and Cd-overloaded mice : An application of the radioactive multitracer technique" Ann.Cli.Lab.Sci.26(6). 531-541 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 天野 良平、他: "Simultaneous tracing of V,Se,Sr,Y,Zr,Ru,and Rh in mice" RIKEN Review. 13. 25-26 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 天野 良平、他: "Comparative uptake behavior oftrace elements in normal,Al-overloaded and Cd-overloaded mice" RIKEN Review. 13. 29-30 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 榎本 秀一、他: "Metabolic and pathological studies on rare-earth elements in non-insulin dependent diabetes mellitus modelmice" RIKEN Review. 13. 31-32 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 大石 茂雄、他、: "Comparative biodistribution ofmultitracers in Wister and LEC rats" RIKEN Review. 13. 31-32 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryohei AMANO,Shuichi ENOMOTO,Motohisa NOBUTA,Manami SAKAMOTO,Rie TSUJIOKA and Fumitoshi AMBE: "Bone uptake of vanadium in mice : Simultaneous tracing of V,Se, Sr, Y,Zr, Ru and Rh using a radioactive multitracer" J.Trace Elements Med.Biol.10 (3). 145-148 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryohei Amano Ph.D., Shigeo Oishi B.Lit., Shuichi Enomoto Ph.D., Fumitoshi Ambe Ph.D.: "Biodistribution of trace elements in normal, Al-overloaded and Cd-overloaded mice : An application of the radioactive multitracer technique" Ann.Cli.Lab.Sci.26 (6). 531-541 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryohei Amano, Shigeo Oishi, Shuichi Enomoto and Fumitoshi Ambe: "Bone accumulation of vanadium Simultaneous tracing of V,Se, Sr, Y,Zr, Ru, and Rh in mice" RIKEN Review. vol.13. 25-26 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryohei Amano, Shigeo Oishi, Shuichi Enomoto and Fumitoshi Ambe: "Comparative uptake behavior of trace elements in normal, Al-overloaded and Cd-overloaded mice" RIKEN Review. vol.13. 29-30 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shuichi Enomoto, Bin Liu, Ryohei Amano, Shizuko Ambe and Fumitoshi Ambe: "Metabolic and pathological studies on rare-earth elements in non-insulin dependent diabetes mellitus model mice" RIKEN Review. vol.13. 31-32 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shigeo Oishi, Ryohei Amano, Atsushi Ando, Shuichi Enomoto and Fumitoshi Ambe: "Comparative biodistribution of multitracers in Wistar and LEC rats" RIKEN Review. vol.13. 33-34 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 天野良平 他: "Unique behavior of rubidium in mice under low oxygen atmosphere:Simultaneous tracing of Sc,Mn,Fe,Co,Zn,Se,Rb,Y and Zr using the radioactive multitrcer technique" Ann.Cli.Lab.Sic.,vol.27(5),pp358-364(1997). 27巻5号. 358-364 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大石茂雄. 天野良平 他: "Simultaneous behavior of Sc,Mn,Fe,Co,Zn,Se,Rb, and Zr trace elements in brain and other organs of C57BL/6N mice" J.Radioanal.Nucl.Chem.,vol.pp.(1998). (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 天野良平、他: "Bone uptake of vanadium in mice : Simultaneous tracing of V,Se,Sr,Y,Zr,Ru and Rh using a radioactive multitracer" J.Trace Elements Med.Biol.10巻3号. 145-148 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 天野良平、他: "Biodistribution of trace elements in normal,Al-overloaded and Cd-overloaded mice : An aplication of the radioactive multitracer technique" Ann.Cli.Lab.Sci.26巻6号. 531-541 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ryohei AMANO他: "Tissue Distribution of 16 Elements in Mice: An application of Multitracer to Animal Experiments" RIKEN Accelerator Progress Report. 28. 90- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Reiko Hirumura他(Ryohei AMANO含む): "Multitracer studies of behavior of trace elements in rats and mice" Journal of Inorganic Biochemistry. 59. 354- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shuichi Enomoto他(Ryohei AMANO含む)20GB03:In vivo behavior of various rare-earth elements in lipogenous diabetes model mice by using the multitracer technique: Journal of Inorganic Biochemistry. 59. 353- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ryohei AMANO他: "Bone Uptake of vanadium in mice: Simultaneous tracing of V, Se, StY, Zr, Ru and Rh using a radioactive multitracer" Journal of Trace Elements in Medicine and Biology. 10(印刷中). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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