• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Synthesis and Specific Properties of Novel Allosteric Host Compounds

Research Project

Project/Area Number 07651027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 有機工業化学
Research InstitutionChiba University

Principal Investigator

YAMAMOTO Makoto  Chiba University : Fac.of Engineering, Dept.of Materials Science Professor, 工学部, 教授 (50039294)

Co-Investigator(Kenkyū-buntansha) KOHMOTO Shigeo  Chiba University : Fac.of Engineering, Dept.of Materials Science Associate Profe, 工学部, 助教授 (90195686)
YAMADA Kazutoshi  Chiba University : Fac.of Engineering, Dept.of Materials Science Professor, 工学部, 教授 (60009230)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsallosteric host / diazacrown ether / metal ion transport / metal complex / molecular recognition / cryptand / hypervalent iodine compound / 金属錯化合物 / エチニルアミン / アザクラウンエーテル
Research Abstract

The author has studied by the above project, and foIIowing results were obtained.
(1). Synthesis and its capturing of metal ion of host compounds bearing flexible cavity were carried out. Pd (II) ion was included at pyridine site of the host compound, but Pb (II), Cu(II) and Zn (II) ions were captured at beta-dicarbonyl site. Host (6) formed the Cu-complex (7) which is again included potassium cation in the newly formed cavity.
(2). Synthesis and Metal ion transport were reported. Spiropyran (6), (7) and (8) transport Cu (lI) ion selectively through liquid membrane. Selective transport experiment of Cu (II) ion from the mixed metal ion solution also reported. Mechanism of this transport was proposed.
(3). Various and direct aminations of acetylenic carbon by iodonium salt were carried out. Using alkylamines, diamines, hydroxylamines, aromatic amines, an amide and isocyanate reacted with phenylethynyliodonium tosylate to give corresponding ethynylamines in good yields. Synthesis were applied to crown-ether derivative and marcocyclic self-assembly compounds. Mechanism was also discussed.
(4). Bis-azacrown ethers (ring size 15 and 18) and cryptands were synthesized. The interaction of these bis-azacrown ethers with dialkali metal salt of dicarboxylic acids in methanol were examined by C-NMR.Bis-azacrown ether (2b), for example, included with dipotassium malonate, 2,2-dibenzylmalonate and terephthalate in its cavity. The other dicarboxylate with bis-azacrown ethers were also examined.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] M.Yamamoto, K.Otsuka, K.Kishikawa and S.Kohmoto: "Lewis Acid Mediaed Addition of Tri(n-butyl)stannylmethyl-isoxazole with Aldehydes" Synthetic Communications. 28. 2177-2187 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Yamamoto, M.Nakazawa, K.Kishikawa and S.Kohmoto: "Niobiun Pentachloride-mediated Novel Homologation Reactions using α-Trialkylstannylmethyl-β-ketoesters" J.Chemical Society,Chemical Communications,. 1996. 2353-2354 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Yamamoto, M.Hirota, K.Kishikawa, S.Kohmoto andK.Yamada: "Oxidative Cyclization of 3-Hydroxy-5-tri(nbutyl)stannyl pentanoic Acids to Corresponding δ-Lactones" Synthesis. 1997年. 937-941 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Yamamoto, K.Itoh, K.Kishikawa and S.Kohmoto: "A Highly Diastereoselective Synthesis of α-Substituted-β-hydroxy Compounds from Corresponding β-Stannyl Componds" Chemistry Letters,. 1997年. 1035-1036 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Yamamoto, M.Nakazawa, K.Kishikawa and S.Kohmoto: "Nibium Pentachloride-mediated Novel Homologation Reactions using α-Trialkylstannylmethyl-β-ketoesters" J.Chemical Society, Chemical Communications. 1996年. 2353-2354 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Yamamoto, M.Hirota, K.Nishikawa, S.Kohmoto and K.Yamada: "Oxidative Cyclization of 3-Hydroxy-5-tri (nbutyl) stanny1 pentanoic Acids to Corresponding δ-Lactones Synthesis" Synthesis. 1997年. 937-941 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Yamamoto, K.Itoh, K.Kishikawa and S.Kohmoto: "A Highly Diastereoselective Synthesis of α-Substituted-β-hydoroxy Compounds from Corresponding β-Stanny1 Compounds" Chemistry Letters. 1997年. 1035-1036 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto,K.Otsuka,K.Kishikawa and S.Kohmoto: "Lewis Acid Mediated Addition of Tri-n-Butylstannylmethylisoxazole with aldehydres" Synthetic Communications. 26. 2177-2187 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Yamamoto,M.Nakazawa,K.Kishikawa and S.Kohmoto: "Niobium pentachloride-mediated novel homologation reactions using α-trialkylstannylmethyl-β-ketoesters" J.Chem.Soc.,Chem.Commun.1996. 2353-2354 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Yamamoto,M.Hirota,K.Kishikawa,S.Kohmoto and K.Yamada: "Oxidative Cyclization of 3-Hydroxy-5-tri (n-butyl) stannylpentanoic Acids to Corresponding δ-Lactones" Synthesis. 1997(印刷中).

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Irie, M. Yamamoto, K. Kishikawa, S. Kohmoto and K. Yamada: "Carbamoyloxa-Bridged Cyclophanes:Macrocycylization by Double Transesterification of Dimethyl-m-xylylenedicarbamate with α,w-Dihydroxy Compounds" Synthesis. 1179-1182 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Yamamoto, K. Ohtsuka, K. Kishikawa and S.Kohmoto: "Lewis Acid Mediated Condensation of Tri-n-butylstannylmethylisoxazole with Aldehydes" Synthetic Communications. 26(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山本忠、科野裕克、田中誠次、砂川博、岸川圭希、幸本重男: "ビス[(β-ケトエステル,β-エナミノン)ポリエーテル]誘導体の合成とそのイオン捕捉能" 日本化学会第69春季年会、講演予稿集I. 4F-536.

    • Related Report
      1995 Annual Research Report
  • [Publications] 山本忠、村山岳志、田中誠次、伊藤潔、岸川圭希、幸本重男: "置換エチニルヨードニウム塩と各種親核試薬との反応" 日本化学会第70春季年会、講演予稿集II. 1H-539.

    • Related Report
      1995 Annual Research Report
  • [Publications] 山本忠、伊藤潔,田中誠次、幸本重男、岸川圭希: "超原子価ヨウ素化合物を用いた置換エチニルアミンの新規合成法" 日本化学会第70春季年会、講演予稿集II. 1H-540.

    • Related Report
      1995 Annual Research Report
  • [Publications] 山本忠、伊藤潔,エディスクル、田中誠次、幸本重男、岸川圭希: "エチニルアミノ基を有するホスト化合物の合成と物性" 日本化学会第70春季年会、講演予稿集II. 1H-541.

    • Related Report
      1995 Annual Research Report
  • [Publications] 山本忠、石川潤、岸川圭希、幸本重男、小熊幸一: "キノリン骨格を有するスピロピランの金属イオン輸送" 日本化学会第70春季年会、講演予稿集II. 2D-202.

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi