| Project/Area Number |
07670003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Chiba University, School of Medicine |
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Principal Investigator |
KOSEKI Haruhiko School of Medicine, Chiba University ; Assistant, 医学部, 助手 (40225446)
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| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | vertebral column / dorsovental axis / Pax-1 / sclerotome / notochord / 体節分化 / コラーゲン(α1) |
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| Research Abstract |
Pax-1 is transcriptional activator containing paired-box as DNA binding domain. From the analysis of Pax-1 deficient mice, Pax-1 was proved to be required for the generation of ventral structures of axial skeleton. To gain further insights for Pax-1 function, I have generated mice over expressing Pax-1 protein. In this mouse, development of caudal vertebral distal region of rib were affected. This result indicates that down regulation of Pax-1 is also important for the morphogenesis of axial skeleton.
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