• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Cardiac sympathetic control of heart excitation rhythm in conscious cats

Research Project

Project/Area Number 07670075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionHIROSHIMA UNIVERSITY (1997)
National Cardiovascular Center Research Institute (1995-1996)

Principal Investigator

MATSUKAWA Kanji  Hiroshima University School of Meidicine, Professor, 医学部, 教授 (90165788)

Co-Investigator(Kenkyū-buntansha) SHIRAI Mikiyasu  National Cardiovascular Center Research Institute.Senior Scientist, 心臓生理部, 室長 (70162758)
二宮 石雄  広島大学医学部, 保健学科, 教授 (80033976)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Keywordscardiac sympathetic nerve activity / cardiac rhythm / autonomic control / behavior / autonomic blocker / 24-hour / renal sympathetic nerve activity
Research Abstract

In this study we examined whether cardiac sympathetic nerve activity (CSNA) conveys neural information specific for the heart, rather than other organs such as the kidneys. To solve this, we measured CSNA,mean arterial blood pressure (MAP), and heart rate (HR) for 24 hour using freely moving conscious cats in combination with autonomic blockades. CSNA,MAP,and HR were sampled at 400 Hz and their mean values over 6 s were sequentially calculated over a 24 hour period. A multivariate correlation analysis was performed fro the 24-hour data. The frequency distribution histograms of CSNA and HR over a 24 hour period were multimodal, while the distribution of AP was unimodal. CSNA had a significant positive correlation with HR,which was blunted by propranolol but not by atropine. CSNA also had a positive correlation with MAP,whose coefficient (0.3-0.4) was smaller than the relationship between CSNA and HR (correlation coefficient, 0.7). If renal sympathetic nerve activity (RSNA) should be related to changes in renal hemodynamics and/or renal function rather than cardiac function, the relationships between RSNA,HR,and MAP must be changed from the relationships between CSNA,HR,and MAP.IN fact, although RSNA had a significant positive correlation with HR,the correlation coefficient (0.4) was smaller than the relationship between CSNA and HR.In conclusion, cardiac sympathetic nerve activity, which conveys neural information specific for the heart rather than the other organs such as the kidneys, is one of the predominant determinant of cardiac excitation rhythm during a 24 hour period. The sympathetic nervous sytem seems to perform a differential and specific control of the physiological function of individual organs.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (41 results)

All Other

All Publications (41 results)

  • [Publications] T.Sadamoto: "Cardiovascular responses during spontaneous overground locomotion in freely-moving decerebrate cats." Jouarnal of Applied Physiology. 83. 1454-1460 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Direct observations of sympathetic cholinergic vasodilatation of skeletal muscle small arteries in the cat." Journal of Physiology. 500. 213-225 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Activity of aortic nerve afferents in conscious,freely-moving cats." Japanese Journal of Physiology. 47(Suppl). S87 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Sadamoto: "Cardiovascular responses during spontaneous overground locomotion in freely-moving decrebrate cats." Japanese Journal of Physiology. 47(Suppl). S87 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Endogeneous nitric oxide attenuates hypoxic vasoconstriction of small pulmonary arteries and veins in anaesthetized cats." Acta Physiologica Scandinavica. 159. 263-264 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "The 24-hour distribution of sympathetic nerve activity to the heart and the kidney in conscious freely-moving cats." FASEB Journal. 10. A334 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Changes in cardiac sympathetic efferent nerve activity,heart rate,and arterial blood pressure associated with voluntary behavior in conscious,freely-moving cats." Japanese Journal of Physiology. 46(Suppl). S38 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 松川 寛二: "意識下行動時の交感神経活動と予測性。" 循環器科. 39. 321-329 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] L.B.Wilson: "Divergence of ventilatory responses to isometric contraction in anesthetized cats." Respiration Physiology. 104. 137-146 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Inhaled nitric oxide:diameter response patterns in feline small pulmonary arteries and veins." American Journal of Physiology. 270. H974-H980 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Differential effects of clonidine on renal sympathetic nerve activity and heart rate at the onset of static exercise." Journal of the Autonomic Nervous system. 51. 205-212 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Sympathetic nervous control of cardiac excitation rhythm over a 24-hour period in awake cats." Japanese Journal of Physiology. 45(Suppl.1). S64 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats." American Journal of Physiology. 269. R1404-R1409 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Effects of baroceptor reflex on efferent pulmonary sympathetic nerve activity in anesthetized cats." American Journal of Physiology. 268. R1078-R1083 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Central control of cardiac sympathetic nerve activity in conscious cats." Abstract of the 4th IBRO World Congress of Neuroscience.432 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 松川 寛二: "循環機能と神経伝達物質。In:中村重信編「神経伝達物質」第2章" 中外医学社(印刷中), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Sadamoto: "Cardiovascular responses during spontaneous overground locomotion in freely-moving decerebrate cats." J.Appl.Physiol.83. 1454-1460 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Direct observations of sympathetic cholinergic vasodilatation of skeletal muscle small arteries in the cat." J.Physiol.(Lond). 500. 213-225 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Activity of aortic nerve afferents in conscious, freely-moving cats." Jap.J.Physiol.47, Suppl.S87 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Sadamoto: "Cardiovascular responses during spontaneous overground locomotion in freely-moving decerebrate cats." Jap.J.Physiol.47, Suppl.S87 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Endogeneous nitric oxide attenuates hypoxic vasoconstriction of small pulmonary arteries and veins in anaesthetized cats." Acta Physiol.Scand.159. 263-264 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "The 24-hour distributiono f sympathetic nerve activity to the heart and the kidney in conscious freely-moving cats." FASEB J.10. A334 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Changes in cardiac sympathetic efferent nerve activity, heart rate, and arterial blood pressure associated with voluntary behavior in conscious, freely-moving cats." Jap.J.Physiol.46, Suppl.S38 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Central and differential control of sympathetic nerve activity during voluntary behaviors." Cardioangiology. 39. 321-329 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] L.B.Wilson: "Divergence of ventilatory responses to isometric contraction in anesthetized cats." Resp.Physiol.104. 137-146 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Inhaled nitric oxide : diameter response patterns in feline small pulmonary arteries and veins." Am.J.Physiol.270. H974-H980 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Differential effects of clonidine on renal sympathetic nerve activity and heart rate at the onset of static exercise." J.Auto, Nerv.System. 51. 205-212 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Sympathetic nervous control of cardiac excitation rhythm over a 24-hour period in awake cats." Jap.J.Physiol.45, Suppl.1. S64 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats." Am.J.Physiol.269. R1404-R1409 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Shirai: "Effects of baroceptor reflex on efferent pulmonary sympathetic nerve activity in anesthetized cats." Am. J.Physiol.268. R1078-R1083 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: "Central control of cardiac sympathetic nerve activity in conscious cats." Abstract of the 4th IBRO World Congress of Neuroscience. 432. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsukawa: Cardiovascular system and neurotransmitters.In : S.Nakamura edited Nuerotransmitters, Chapter 2. (in Japanese). Cyugai-Igaku (in press), (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Sadamoto: "Cardiovascular responses during spontaneous overground locomotion in freely-moving decerebrate cats." Journal of Applied Physiology. 83. 1454-1460 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Matsukawa: "Direct observations of sympathetic cholinergic vasodiatation of skeletal muscle small arteries in the cat." Journal of Physiology. 500. 213-225 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Matsukawa: "Activity of aortic nerve afferents in conscious,freely-moving cats." Japanese Journal of Physiology. 47. Suppl:S87 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Sadamoto: "Cardiovascular responses during spotaneous overground locomotion in freely-moving decerebrate cats." Japanese Journal of Physiology. 47. Suppl : S87 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Shirai: "Endogeneous nitric oxide attenuates hypoxic vasoconstriction of small pulmonary arteries and veins in anaesthetized cats." Acta Physiologica Scandinavica. 159. 263-264 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 松川寛二: "循環機能と神経伝達物質。In:中村重信編「神経伝達物質」第2章。" 中外医学社(印刷中), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.MATSUKAWA: "Changes in cardiac sympathetic efferent nerve activity,heart rate,and arterial blood pressure associated with voluntary behavior in conscious,freely-moving cats." Jap.J.Physiol.Vol.46,Suppl. S38 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K. MATSUKAWA: "The 24-hour distribution of sympathetic nerve activity to the heart and the kidney in conscious free-moving cats." FASEB J.(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. MATSUKAWA: "Central control of cardiac sympathetic nerve activity in conscious cats" Abstract of the 4th IBRO World Congress of Neuroscience. 432- (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi