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Physiological significance of exhaled nitric oxide during exercise

Research Project

Project/Area Number 07670077
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionAsahikawa Medical College

Principal Investigator

IWAMOTO Jun  Asahikwa Medical College DeptPhysiology, Associate Professor, 医学部, 助教授 (20160137)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsNITRIC OXIDE / NASAL RESISTANCE / EXERCISE / EXHALED GAS / 化学発光 / 呼気NO
Research Abstract

While the exhaled gas passes through upper airway and nasal cavity, i t acquires nitric oxide (NO) in these sites. The final origin of NO in the airway is not clear, but it seems that NO may diffuse out of the airway epithelia to the lumens. In order to estimate the outflux of NO in the airway, we have measured the exhaled NO from the nasal cavity and mouth separately. For this purpose we have developed a real-time measurement system for exhaled NO.This device can automatically measure both NO concentration and VNO.VNO,of which unit is nl/min, is a production rate for exhaled NO.This parameter is the only useful tool to estimate the amount of NO from the airway.
1. Nasal NO
We studied human nasal NO in healthy volunteers. The subject was asked to perform a voluntary closure of soft palate (VCSP) in order to ventilate nasal airway from the right (or left) nostril to the left (or right). The VNO of the nose was measured approximately 300 nl/min. After 4 min of moderate exercise, the VNO wa … More s significantly decreased by 30%. The close measurement of NO in the nose with an inserted tube revealed that the nasal NO has pattern of oscillation which synchronized with that of pulsatile changes of nasal mucosal blood flow. These results suggest that the nasal NO is arising from epithelia and/or vascular bed of nasal mucosa.
2. NO from lower airway
The real-time measurement clarified many unknown aspects of exhaled NO.The pattern of single breath of exhaled NO (VNO) is always peaked at the early period of expiration (0.1 to 0.3 sec after beginning of expiration) and tapered abruptly in the end-expiratory period. This suggests that NO in the lower airway may originate in the sites close to the alveolus, probably periphery to terminal bronchioles. The breath hold can increase VNO simply depending on the breath hold time. The linear relationship between VNO and the time strongly suggests that NO is continuously sprung from the airway wall at constant rate. Another interesting finding was that alveolar ventilation is correlated with VNO.This suggests that NO is picked up by the alveolar gas while it is passing by. In conclusion, NO production in the airway is stable and continuous during resting and measurable in a unit of VNO. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 岩元純: "一酸化窒素測定装置" 循環制御. 16. 18-23 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Imade M: "Measurement of nitric oxide in human nasal airway." Eur. Respir. J. 9. 556-559 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwamoto, J.: "Breath‐by‐breath measurement of exhaled nitric oxide (NO) by chemiluminescence during exercise." FASEB J.10(3). A330- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogasa, T: "Blood attenuates flow dependent increase in exhaled NO in buffer‐perfusde rabbit lungs." Am J Resp Crit Care Med. 153(4). A186- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakano, H: "Hypoxia decreases exhaled NO in isolated buffer-perfused rabbit lungs." Am J Resp Crit Care Med. 153(4). A186- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwamoto, J: "Pulsatile excretion of human nasal nitric oxide measured by a fast real-time detection system." Am J Resp Crit Care Med. 153(4). A851- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwamoto, J.: "The physiological basis for NO therapy: factors that may affect effectiveness of exogenous NO" Program & Abstracts Fourth Congress of Asia Pacific Association for Raspiratory Care Seventh Seminar for Respiratory Care. 201-205 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 戸苅創 他: "新生児NO吸入療法" 新生児NO吸入療法研究会・編, 169 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwamoto, J., Imada, M., Unno, T., Nonaka, S., and A.Kuroshima: "Nasal nitric oxide decreases along with nasal airway resistance after exercise." Jpn.J.Physiol. 45 (suppl. 2). S280 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwamoto, J., Ogawa, K., Suzuki, Y., Nakano, H.and Kuroshima, A.: "Breath-by breath measurement of exhaled nitric oxide (NO) by chemiluminescence during exercise." FASEB.J.10 (3). A330 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogasa, T., Nakano, H., Iwamoto, J., Ide, H., Takahashi, H., Akiba, Y., and Kikuchi, K.: "Blood attenuates flow-dependent increase in exhaled NO in buffer-perfused rabbit lungs." Am J Resp Crit Care Med. 153 (4). A186 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakano, H., Ogasa, T., Iwamoto, J., Ide, H., Takahashi, H., Akiba, Y., and Kikuchi, K.: "Hypoxia decreases exhaled NO in isolated buffer-perfused rabbit lungs." Am J Resp Crit Care Med. 153 (4). A186 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwamoto, J., Imada, M., Nakano, H., Ogasa, T.: "Pulsatile excretion of human nasal nitric oxide measured by a fast real-time detection system." Am J Resp Crit Care Med. 153 (4). A851 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Imada, M., Iwamoto, J.Nonaka S,Kobayashi Y,Unno T.: "Measurement of nitric oxide in human nasal airway." Eur.Respir.J.9. 556-559 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岩元純: "一酸化窒素測定装置" 循環制御. 16. 18-23 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Imada M: "Measurement of nitric oxide in human nasal airway." Eur.Respir.J.9. 556-559 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iwamoto,J.: "Breath-by-breath measurement of exhaled nitric oxide (NO) by chemiluminescence during exercise." FASEB J.10(3). A330 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ogasa,T.: "Blood attenuates flow-dependent increase in exhaled NO in buffer-perfused rabbit lungs." Am J Resp Crit Care Med. 153(4). A186 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakano,H.: "Hypoxia decreases exhaled NO in isolated buffer-perfused rabbit lungs." Am J Resp Crit Care Med. 153(4). A186 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iwamoto,J.: "Pulsatile excretion of human nasal nitric oxide measured by a fast real-time detection system." Am J Resp Crit Care Med. 153(4). A851 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 戸刈創他: "新生児NO吸込療法" 新生児NO吸込療法研究会・編, 169 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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