| Project/Area Number |
07670082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
IWASE Satoshi Nagoya University, Research Institute of Environmental Medicine, Associate Professor, 環境医学研究所, 助教授 (90184879)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUKAWA Toshiyoshi Nagoya University, Research Institute of Environmental Medicine, Assistant Profe, 環境医学研究所, 助手 (60252293)
SUGIYAMA Yoshiki Nagoya University, Research Institute of Environmental Medicine, Assistant Profe, 環境医学研究所, 助手 (50240809)
MANO Tadaaki Nagoya University, Research Institute of Environmental Medicine, Professor, 環境医学研究所, 教授 (30023659)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Skin sympathetic nerve activity / Sweating / Skin blood folw / Regional deifferentiation of sympathetic outflow / Mental sweating / Thermal sweating / Microneurography / Double recording technique |
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| Research Abstract |
Microneurographically recorded skin sympathetic nerve activity (SSNA) contains sudomotor and vasoconstrictor activities. We investigated how ambient temperature modulates these two activities using double recording technique of microneurography, simultaneously from the tibial and the peroneal nerves, in normohidrosis and sweating disorders. Simultaneous measurement of sweat expulsion and skin blood flow under neutral ambient temperature enables this differentiation, but it might be difficult under high and low ambient temperatures due to uncertain effector response. Based on the changes in effector organs under neutral temperature, we made interspike interval histogram (ISIH), and challenged the differentiation of the tibial and peroneal SSNA_s under high (35ﾟC) and low (15ﾟC) ambient temperatures by using the spike matching method. The differentiation was turned out to be possible to sudomotor and vasoconstrictor impulses under any ambient temperature not only in burst level, but also in spike level. Moreover, the regional differentiation of sympathetic nerve activity became manifested as the differences in sympathetic nerve activities supplying glabrous and hairy skin by warming or cooling the ambient temperatures. Ambient temperature rise induced activation of vasodilative component in SSNA in the peroneal but not in the tibial in the normohidrosis, however, enhancement of tibial sudomotor and vasoconstrictor activities were manifested in the tibial nerve in palmoplantar hyperhidrosis. Lowering the ambient temperature suppresses the sudomotor activity in the peroneal, whereas it activates in the tibial. These results suggest significant findings in analyzing the effects of ambient temperature and mental stress on thermoregulation of human body temperature.
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