| Project/Area Number |
07670273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUJITA Koichiro Tokyo Medical and Dental University, Faculty of Medicine, Professor, 医学部, 教授 (90053107)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKIDATE Setsuko Tokyo Medical and Dental University, Faculty of Medicine, Research fellow, 医学部, 助手 (40121256)
AKAO Nobuaki Tokyo Medical and Dental University, Faculty of Medicine, Lecturer, 医学部, 講師 (00126559)
宮坂 信之 東京医科歯科大学, 医学部, 教授 (30157622)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Th1 / Th2 / Brugia pahangi / Plasmodium berghei / IL-4 / IL-5 / IgE / IL-5 / Brugia pahani / Plasmodium bergi |
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| Research Abstract |
This study investigates the course of Plasmodium berghei malaria infection in CBA/J mice inoculated with irradiated attenuated 3rd-stage larvae (L3) of Brugia pahangi. Peripheral eosinophil counts, serum IgE levels and cytokine production revealed that the filarial antigen induced T-helper type 2 (Th2) cell predominance in these mice, which protected them against the development of cerebral malaria. These mice significantly prolonged their survival, compared with the control mice after P.berghei infection. All of the mice not inoculated with irradiated L3 died within 12 days with acute neurological manifestations unrelated to the level of parasitaemia after infection of P.berghei. Conversely, most of the inoculated mice lived more than 3 weeks following infection with P.berghei, dying in the fourth week of severe anemia and overwhelming parasitaemia. This suggests that Th2-dominant responses lead to the down-regulation of susceptibility to murine cerebral malaria.
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