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REGULATION OF INFLAMMATORY AND ALLERGY RESPONSES BY ANTI-LFA-1 MONOCLONAL ANTIBODY

Research Project

Project/Area Number 07670382
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionTOKAI UNIVERSITY

Principal Investigator

NISHIMURA Takashi  TOKAI UNIVERSITY,SCHOOL OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (30143001)

Co-Investigator(Kenkyū-buntansha) HABU Sonoko  TOKAI UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (30051618)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsTh1-Th2 balance / liver injury / allergy / LFA-1 / T cells / IL-12 / IgE / Cytokine / 炎症
Research Abstract

In this project, we demonstrated that mouse liver injury model induced by propionibacterium acnes (P.acnes) plus LPS is T cell-dependent one judging from the experiment using T cell deficient nude mice. Because the liver injury was completely blocked by anti-LFA-1 mAb, LFA1-ICAM-1 interaction is essential for the activation and migration of effector cells to liver. It was also demonstrated that Th1-activating cytokine, IFN-gamma and IL-12 are key cytokines in this liver injury model. C57BL/6 mice, which are prone to show Th1 immunity, are sensitive to P.acnes plus LPS-induced liver injury, while BALB/c showing Th2 immunity are resistant to this. Therefore, genetically-controlled Th1/Th2 balance appeared to be important factor the induction of liver injury.
The important role of LFA-1 molecule in allergy is also demonstrated from the evidence that anti-LFA-1 mAb administration inhibited IgE production in vivo for long-term.
Thus, the important role of LFA-1 molecule and Th1-Th2 balances in the regulation of liver inflammatory responses and allergy was clearly demonstrated by this project.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Sato,N.,et al.: "Functional characterization of Ly-6C^+NK1・1^+cells" Immunol.Letters. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tanaka,Y.,et al.: "Productive and lytic infection of human CD4^+type 1 helper T cells with macrophage-topic human immunodeficiency virus type 1." J.Virol.71. 465-470 (1977)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura,T.et al.: "The application of IL-12 to cytokine and gene the rapy of tumor." Ann.NY.Acad.Sci.795. 375-378 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura,T.et al.: "The therapeutic effect of IL-12 or its antagonist in transplantation immunity." Ann.NY.Acad.Sci.795. 371-374 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura,T.et al.: "The application of IL-12 to antitumor cytokine and gene therapy." Cancer Chemother.Pharmacol.38. S27-S34 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tanaka,Y.et al.: "A pivotal role of inferleukin-12 in Thl-dependent mouse liver ingury." Int.Immunol.8. 569-576 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sato.N et al.: "Functional characterization of Ly-6C^+NK1.1^+ cells" Immunol.Letters. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tanaka, Y.et al.: "Productive and lytic infection of human CD4_+ type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1." J.Virol. 71. 465-470 (1977)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura, T.et al.: "The application of IL-12 to cytokine and gene therapy of tumor." Ann.NY.Acad.Sci.795. 375-378 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura, T.et al.: "The therapeutic effect of IL-12 or its antagonist in transplantation immunity." Ann.NY.Acad.Sci.795. 371-374 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishimura, T.et al.: "The application of IL-12 to antitumor cytokine and gene therapy." Cancer Chemother.Pharmacol.38. S27-S34 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tanaka, Y.et al.: "A pivotal role of interleukin-12 in Th1-dependent mouse liver injury." Int.Immunol.8. 569-576 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sato,N.et al.: "Functional characterization of Ly-6C^+ NK1-1^+ cells." Immunol.Letters. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,Y.et al.: "Productive and lytic infection of human CD4^+ type I helper T cells uith macrophage-tropic human immunodeficiency virus typel." J.Virol.71. 465-470 (1977)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishimura,T.et al.: "The application of IL-12 to cytokine and gene therapy of tumor." Ann.NY.Acad.Sci.795. 375-378 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishimura,T.et al.: "The therapeutic effect of IL-12 or its antagonist in fransplantation immunity." Ann.NY.Acad.Sci.795. 371-374 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishimura,T.et al.: "The application of IL-12 to antitumor cytokine and gene therapy." Cancer Chemother.Pharmacol.38. S27-S34 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,Y.et al.: "A pivotal role of interleukin-12 in Th1-dependent mouse liver injury." Int.Immunol.8. 569-576 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka, Y.: "A pivotal role of interleukin-12 in Thl-dependent mouse liver injury" Int. Immunol.in press.

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka, Y.: "Prolonged inhibition of an antigen-specific IgE response in vivo by monoclonal antibody against lymphocyte function-associated antigen-1" Eur. J. Immunol.25. 1555-1558 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka, Y.: "Establishment of a T cell-dependent nude mouse liver injury model induced by propionibacterium acnes and LPS." J. Immunol. Method. 182. 21-28 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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