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Toxicity of heat decomposed products of halon alternative fire extinguishing agents.

Research Project

Project/Area Number 07670410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKeio University

Principal Investigator

UEMURA Takamoto  Keio University, School of Medicine Assistant, 医学部, 助手 (10232795)

Co-Investigator(Kenkyū-buntansha) TAKEBAYASHI Toru  Keio University, School of Medicine Lecturer, 医学部, 専任講師 (30265780)
OMAE Kazuyuki  Keio University, School of Medicine Associate Professor, 医学部, 助教授 (60118924)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsHalon alternative fire extinguishing agents / Hydrogen Fluoride / LC_<50>
Research Abstract

The study aimed to clarify lethal dose 50 (LC_<50>) and the acute pulmonary toxicity of heat decomposed gas of 1,1,1,2,3,3,3-Heptafluoropropane (HEP,CF_3CHFCF_3), which is one of halon alternative fire extinguishing agents, on male ICR mice. Exposure levels of the decomposed gas sampled in inpingers were expressed as an equivalent dose of hydrogen fluoride (HF). 1. To clarify LC_<50> of heatdecomposed gas of HFP,five groups of ten mice each were exposed to 87.0,173.3,237.8,456.5,709.6 ppm of the gas for one hour. LC_<50> of the gas was estimated to be 463ppm, which is similar to LC_<50> of hydrogen fluoride, 500ppm. 2. To clarify the acute pulmonary toxicity of heat decomposed gas, five groups of five mice were exposed to the same concentration of the gas as 1. After exposure, the hematological, biochemical and histopathological examinations were performed. In higher exposed group, desquamation of alveolar epithelial cells and decrease of calcium in serum were seen.
These results suggested that heat decomposed gas of HFP caused pulmonary inflammation and epithelial cell damage.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 小田 健一: "ハロン代替消化剤熱分解産物の毒性-Heptafluoropropaneについて-" 産業衛生学雑誌. 38. 5551 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 大前 和幸: "フロン系消化剤の熱分解産物の吸入毒性" 第26回安全工学シンポジウム講演予稿集. 183-184 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] ODA K et al.: "Toxicity of heat decomposed products of halon alternative fire extinguishing agent : Heptafluoropropane (in Japanese)" San Ei Shi. 38. s551 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Omae K et al.: "Inhalable toxicity of heat decomposable products of halon alternative fire extinguishing agents. (in japanese)" Contents of the 26th symposium of safety engineering. 183-184 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 小田健一: "ハロン代替消火剤熱分解産物の毒性-Heptafluoropropaneについて-" 産業衛生学雑誌. 38. S551 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大前和幸: "フロン系消火剤の熱分解産物の吸入毒性" 第26回安全工学シンポジウム講演予稿集. 183-184 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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