| Project/Area Number |
07670420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Tohoku University |
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Principal Investigator |
TSUJI Ichiro Tohoku University School of Medicine, Department of Public Health, Associate Professor, 医学部, 助教授 (20171994)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Yutaka Tohoku University School of Medicine, Department of Internal Medicine, Assistant, 医学部・付属病院, 講師 (40133946)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Blood Pressure / Home Blood Pressure Measurement / Ambulatory Blood Pressure Measurement / Magnetic Resonance Imaging (MRI) / Asymptomatic Cerebral Infarction / Mortality / Cohort Study / Epidemiology |
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| Research Abstract |
We have been measuring home blood pressure (HBP), 24-hr ambulatory blood pressure (ABP), and casual blood pressure (CBP) on 4500 residents at Ohasama, Iwate Prefecture, Japan since 1987, and following up their health-related outcome.
We compared predictive power for mortality among the above three methods for blood pressure (BP) measurement. The results indicated that predictive power of both HBP and ABP levels for mortality was stronger than that of casual screening BP.Based on this relation between HBP values and mortality, we propose that the reference value for hypertension is 137/84 mmHg, and normotension is below 137 mmHg for home systolic BP and between 66 and 83 mmHg for home diastolic BP.Home diastolic BP below 66 mmHg should be considered as low diastolic blood pressure.
We investigated the effect of nocturnal decline of BP upon development of silent cerebral infarction. For this purpose, we performed magnetic resonance imaging (MRI) test of the brains on randomly sampled 151 individuals aged 65 years and over. The results indicated that the amplitude or the rate of the fall in nocturnal blood pressure in elderly women with one or two lacunar infarctions was significantly higher than that in those without such infarctions. There was a significant positive correlation between the amplitude or the rate of the fall in nocturnal blood pressure and the extent of periventricular hyperintensity in the elderly women. This relationship was observed in women, but not in men, of late middle age ; this was not seen in elderly men. Treatment of hypertension in such women should be administered with care and with regard to nocturnal blood pressure.
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