| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
Recent studies of polyunsaturated fatty acids (PUFA) in plasma and blood cell components of patients with atopic diseases have indicated disordered fat metabolism as linoleic acid (18 : 2n-6) tends to be increased while the more unsaturated fatty acids, such as gamma-linolenic acid (18 : 3n-6) and arachidonic acid (20 : 4n-6) are present in decreased amounts. In atopic eczema patients, the delta-6-desaturase function should be impaired, then the amount of linoleic acid should be increased, on the other hand those of the linoleic acid metabolites should be decreased. And so when the direct metabolite of linoleic acid, gamma-linolenic acid, is adminostered for the patients, then the symptoms of this disease should be disappeared.
No significant differences were seen between control and patients before treatment. By the treatment of EFA,dihomogamma-linolenic acid (20 : 4n-6) was significantly decreased and behenic acid (22 : 1n-9? ) significantly increased.
Linoleic acid (18 : 2n-6) of patients looked like to be increased compared with control group and decreased after treatment, though not significantly. And more unsaturated fatty acids, such as homogamma-Iinolenic acid and arachidonic acid looked decreased after treatment.
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