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Alcohol metabolism in women and hormonal changes.

Research Project

Project/Area Number 07670487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionMie University

Principal Investigator

FUKUNAGA Tatsushige  Faculty of Medicine, Professor, 医学部, 教授 (70156800)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hidetaka  Mie University, Faculty of Medicine, Research Associate, 医学部, 助手 (90158296)
TANEGASHIMA Akio  Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (70283520)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsAlcohol / Acetaldehyde / Polymorphism / Alcohol dehydrogenase / Aldehyde dehydrogenase / Gender differences / Estrogen / Testosterone / Alcohol dehydrogenase / Aldehyde dehydrogenase / Gender difference / Acetal dehyde / Aldebyde dehydrogenase
Research Abstract

Alcohol is more often unpleasant and causes tissue damage more rapidly in women than men. The present study was designed to find out whether acetaldehyde, the first metabolite of alcohol, could play a crucial role in these actions. Alcohol (dose : 0.1g/kg) was orally taken by healthy Jpanese female subjects in two different stages of menstrual cycle. These data were compared with those of Caucasians.
Blood acetaldehyde levels were influenced by the genotype of aldehyde dehydrogenase 2, but not alcohol dehydrogenase 2. An association between elevated acetaldehyde levels and high-estrogen phases was observed. Estrogen related acetaldehyde elevation is suggested to be the key factor explaining the gender differences regarding the adverse effects of alcohol.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Eriksson, C. J. P. et al.: "Estrogen-related acetaldehyde elevation in women during alcohol intoxication." Alcohol. Clin. Exp. Res.20. 1192-1195 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Eriksson, C.J.P., et al.: "Estrogen-related acetaldehyde elevation in women during alcohol intoxication." Alcohol.Clin.Exp.Res.20. 1192-1195 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Eriksson,C.J.P.et al.: "Estrogen-related acetaldehyde elevation in women during alcohol intoxication." Alcohol.Clin.Exp.Res.20・7. 1192-1195 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Erikosom C.J.P.Fukunaga,T.et al.: "Estrogen-related acetaldehyde elevation in women during alcohol intocication" Alcoholism:Clin.Exp.Res.(印刷中). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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