| Project/Area Number |
07670487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Mie University |
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Principal Investigator |
FUKUNAGA Tatsushige Faculty of Medicine, Professor, 医学部, 教授 (70156800)
|
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hidetaka Mie University, Faculty of Medicine, Research Associate, 医学部, 助手 (90158296)
TANEGASHIMA Akio Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (70283520)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Alcohol / Acetaldehyde / Polymorphism / Alcohol dehydrogenase / Aldehyde dehydrogenase / Gender differences / Estrogen / Testosterone / Alcohol dehydrogenase / Aldehyde dehydrogenase / Gender difference / Acetal dehyde / Aldebyde dehydrogenase |
|---|
| Research Abstract |
Alcohol is more often unpleasant and causes tissue damage more rapidly in women than men. The present study was designed to find out whether acetaldehyde, the first metabolite of alcohol, could play a crucial role in these actions. Alcohol (dose : 0.1g/kg) was orally taken by healthy Jpanese female subjects in two different stages of menstrual cycle. These data were compared with those of Caucasians.
Blood acetaldehyde levels were influenced by the genotype of aldehyde dehydrogenase 2, but not alcohol dehydrogenase 2. An association between elevated acetaldehyde levels and high-estrogen phases was observed. Estrogen related acetaldehyde elevation is suggested to be the key factor explaining the gender differences regarding the adverse effects of alcohol.
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