| Project/Area Number |
07670500
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
FUJIMIYA Tatsuya Kyoto Prefectural University of Medicine, Medicine, Associate Professor, 医学部, 助教授 (50219044)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHBORA Yumiko Kyoto Prefectural University of Medicine, Medicine, Research Assistant, 医学部, 助手 (90079757)
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | Alcohol / Pharmacokinetics / Population Pharmacokinetics / Drug-drug Interaction / Noncompetitive Inhibition |
|---|
| Research Abstract |
Fundamental studies on population pharmacokinetics of alcohol and alcohol-drug interaction were conducted. At first, the technical problems of the pharmacokinetic analysis of alcohol disposition were studied using the Michaelis-Menten elimination kinetics models. The ordinary least-squares (OLS) method was compared with the Baysian least-squares (BLS) method. Correlation between the V_<max> and beta values, and between the V_<max> and K_m values, was seen when the parameter values were estimated by the OLS method. These results suggested that one-line fitting by the OLS method was not adequate for Michaelis-Mentan-type elimination kinetics analysis.
At second, the pharmacokinetic mechanism of the inhibition of ethanol metabolism by cyanamide, an inhibitor of mitochondrial aldehyde dehydrogenase, was studied. As a result, the estimated V_<max> values decreased by cyanamide treatment, whereas the K_m value did not change. Our results correspond to a noncompetitive-like inhibition of ethanol metabolism. This result is thought to be an example of alcohol-drug interaction.
|
