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Mechanism of allergic inflammation by global environmental pollutant substance vanadium

Research Project

Project/Area Number 07670527
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionUniversity of Tokyo

Principal Investigator

KITANI Seiichi  University of Tokyo Assistant professor, 医学部・付属病院, 助手 (10231284)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Atsuko  University of Tokyo Faculty of Medicine Staff, 医学部・付属病院, 医員
KIHARA Hidetoshi  University of Tokyo Faculty of Medicine Staff, 医学部・付属病院, 医員
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Keywordsvanadium / allergy / environment / mast cell / アレルギー性炎症 / 酸化バナジウム
Research Abstract

Vanadium is contained in fossil fuel such as coal, oil and sand oil and released in the air through the combustion. We studied the allergic and inflammatory potentials of vanadium as the factor of a recent increase of allergic disease.
Vanadium oxide (V_20_5) and orthovanadate (N_3VO_4) released histamine from human basophils, rat mast cells and rat basophilic leukemia (RBL-2H3) cells in the presence of hydrogen peroxide (H_20_2). Activation of RBL-2H3 cells by vanadium/H_20_2 was accompanied by leukotriene synthesis, increases of [Ca^2]i, multiple protein tyrosine phosphorylations and remarkable morphological changes. Pharmacological study using FK506 and wortmannin suggests that vanadium/H_20_2 activates mast cells at the late phase. bypassing the early signaling components. This (was also confirmed with the experiments of desensitization and IgE-responsiveness of non-releasing human basophils.
We report here the allergic capacity of vanadium and the radicals, including the the modulation of H_20_2 in local allergic inflammation sites. Our results give the alarm of global environmental crisis of industrial society from allergic point of view and indicate the possible selection of policy in law enforcement and sustained economical development.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Kitani S: "Global ennironmental pollutant substance vanadium activates mast cell and besovbib at the late phase in the preience of H_2 O_2" Envirou. Tokicol. Pharimacal.6. 1-12 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitani S: "Global environmental pollutant substance vanadium activictos nast cell and basophils" Advances in the prevention of Occupational respiratory Disease. 769-771 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furuno.T: "Surface expression of CD63(AD1) in P815 mastocytoma cells" Biochem, Biophys, Res, Commun.219. 740-744 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitani S: "The effect of okudaic acid on RBL-2H3 human basophil as compared with not most cell" Int.Arch Alleray Immunol. 110. 339-347 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki M: "A pharmacological study of basophil histamine release induced by monocyte chemotactic and activating factor" Int.Arch Alleray Immunol. 112. 18-22 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yumaguchi: "Non-releasing basophils are converted int. releasing basophils culturery with interlenkin-3" J.Allargy Clin Innunol. 97. 1279-1287 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitani S,De Silva NR,Morita Y,Teshima R: "Global environmental pollutant substance vanadium activates mast cells and basophils at the late phase in the presence of hydrogen peroxide" Environ.Toxicol.Pharmacol. 6. 1-12 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitani S,De Silva NR,Morita Y,Teshima R: "Global environmental pollutant substance vanadium activates mast cells and basophils. Advances in the Prevention of Occupational Respiratory Disease." K.Chiyotani, Y.Hosoda and Y.Aizawa, editors Elsevier/Amsterdam. 769-771 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furuno T., Teshima R., Kitani S.et al.: "Surface expression of CD63 antigen (ADl antigen) in P815 mastocytoma cells by transfected IgE receptors." Biochem.Biophys.Res.Commun.219. 740-744 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitani, S., Teshima, R., Nonomura, Y., Morita, Y., Ito, K.: "The effect of okadaic acid on rat basophilic leukemia (RBL-2H3), human basophil as compared with rat mast cell." Int.Arch.Allergy.Immunol.110. 339-347 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki, M., Hirai, K., Kitani, S., Takaishi, T., Kihara, H., Kasahara, T., Ito.K., Morita, Y.: "A pharmacological study of basophil histamine release induced by monocyte chemotactic and avtivating factor with kinase inhibitors." Int.Arch.Allergy.Immunol.111. 18-22 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamaguchi-M,Hirai-K,Ohta-K,Suzuki-K,Kitani-S,Takaishi-T,Ito-K,Ra-C,Morita-Y: "Nonreleasing basophils are converted into releasing basophils by culturing with interleukin-3." J-Allergy-Clin-Immunol.97. 1279-87 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitani S et al.: "Global environmental pollutant sutetance vanadium activictos mast icll basophils at the lato phare" Environmental Toxicology and Pharmacology. (accepted).

    • Related Report
      1997 Annual Research Report
  • [Publications] Teshima R and Kitani S.: "Effect of an ectokinase inhibitor,K25・2b,on dogranulation and Ca^<2+> signals of RBL-2H3 cells and human basophils." J.Immunol.I. 159. 964 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 木谷誠一: "アレルギー性疾患" 認定医専門医のための内科学レビュー(総合医学社). 単行本. 284-288 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 木谷誠一: "アレルギー性気管支肺アスペルギルス症-症態と治療" 内科(南江堂). 81.3. 510-513 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Kitani et al: "Global environmentel pollutant substance vanadium activate mast cell and basophils" The 9th International conference on occupotional allergy disaase(Kyoto). 92 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 木谷誠一 他: "環境汚染物質バナジウムによる肥満細胞活性化" 気管支喘息の発症機序に関する研究報告書. 平成9年2月. 55-78 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitani S.et al.: "The effect of okaduic acid on rat basophilic leukemia,human basophil as compared with rat mast cell" Int.Arch.Allergy.Immunol. 110. 339-347 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Furuno T.et al.: "Surface express.,or CD63 antigen in P815 martucytoma cells by transtectol I,E recouture." Biochem.Biochys.Res.Commun.219. 740-744 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nagai S.et al.: "Pharmacological study of stem-cell tactor induced want cell histamine release" Biochem.Biochys.Res.Commun.208. 576-581 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamaguchi M.et al.: "Non releasing basophils are couverted into releasuy basophils by culturing with interleukin 3" J.Allergy Clin.Immunol. 97. 1279-1287 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Suzuki M.et al.: "A phamacological study of basophil histamine release induced bymonociate chemotactic and actiuatig facter" Int.Arch.Allergy.Immunol. 111. 18-22 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitani S.: "The effect of okadaic acid on rat basophilic leukomia(RBL-2H3)" Int. Arch. Allergy Immunol.in press. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Furuno T.: "Surtace expression of CD63 antigen (ADI antigen) in P815 wastocytona" Biochem Biophys Res.Commun. in press. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nagai S: "Pharma cologicl study of stem-cell qactin in duced mast cell hitagus relacne" Biochem Biophys Res. Commun. 208. 576-581 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamaguchi M: "Nonroleasing basophils are converted into releasing basophils by culturing with interlenhin 3" J.Allergy Clin Immunal. in press. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Teshima: "Isolation and characterization of a major allergenic component ot Aspergillus fumigatus" J.Allergy Clin Immunal. 92. 698-706 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kitan S: "Inhibition of IgE-mediater histamine release by myosin light chain hirase inhibitors" Biochem Biophys Res Commun. 183. 48-54 (1992)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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