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The effects of acfirin A in liver generation

Research Project

Project/Area Number 07670565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionUniversity of Tokyo

Principal Investigator

MINE Tetuya (1996)  University of Tokyo, Faculty of Medicine, 医学部・附属病院(分), 講師 (20157572)

安田 宏 (1995)  東京大学, 医学部・附属病院(分), 助手 (80262129)

Co-Investigator(Kenkyū-buntansha) 峯 徹也  東京大学, 医学部・附属病院(分), 助手 (20157572)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsActivin A / Follistatin / Liver regeneration / activin receptor / partial hepatectomy / アクチビン / 伊東細胞
Research Abstract

To determine the role of activin A in liver regeneration, the effects of exogenous follistatin, which blocks the action of activin A,were examined. A single adiministration of follistatin into the portal vein accelerated the initial round of DNA synthesis. Furthermore, we also demonstrated that intravenous administration of follistatin also accumulate in the liver and promotes liver regeneration after partial hepatectomy as well as administration into portal vein. Furthermore, we investigated the characterization of the activin receptor using cultured rat hepatocytes.The results indicate that two classes of activin A binding sites existed in cultured hepatocytes : the high-affinity binding site may represent oligomeric complex of the type I and II receptors and at least part of the low-affinity binding site may represent cell-bound follistatin. The number of activin receptors in hepatocytes was increased after the stimulation with EGF.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Mine Tetsuya: "Norepinephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes." Hepatology. 23. 288-293 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Betacellulin and activinA wordinately convert amylase-secreting pancreatic AR42J cells into insullin-secreting cells." Journal of Clinical Investigation. 97. 1647-1654 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Effects of inhibin on activin A induced glucose metabolism in rat hepatology." Endcrine. 5. 41-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Formation of insullin-producingcells from AR42J cells by hepatocyte growth factor." Endcrinology. 137. 3969-3976 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Characterization of the activin receptor in cultured rat hepatocytes." Hepatology. 24. 446-450 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Presence of conneyin32 on various kinds of gastritis" (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Norepihephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes." Hepatology. 23. 288-293 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Bctacellulin and activin A cuordinately conaert amylase-secreting pasclecrtic AR42J cells into insullin-secreting cells" Journal of Clinical Investigation. 97. 1647-1654 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Effects of inhibin on activin A induced glucose netabulism in rat.hepatology." Endcrine. 5. 41-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Furmation of insallin-producing cells from AR42J cells by hepatocyte growth factor." Endcrinology. 137. 3969-3976 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Characterization of the activin receptor in caltured rat hepotocytes" Hepatology. 24. 446-450 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Presence of connxin32 on various kinds of gastritis" (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mine Tetsuya: "Naepimphrine reverses the effects of actirinA on DNA syntesis and apeptosis in ultured rat hepatocytes." Hepatology. 23. 288-293 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mine Tetsuya: "Betacellulin and actirinA coordinately convert amylase-secreting panieatic AR 42J cells into insullin-secreting cells." Journal of Clinical Investigation. 97. 1647-1654 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mine Tetsuya: "Effects of inhibin actirinA induced glucose metabolism in rat hepatocytes." Endcrine. 5. 41-46 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mine Tetsuya: "Formation of insulin-producing cells from AR 42J cells by hepatocyte growth factor." Endocrinology. 137. 3969-3976 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mine Tetsuya: "Characterization of the actirin receptor in cultured rat hepatocytes." Hepatology. 24. 446-450 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mine Tetsuya: "Presence of connexin32 on rarious kinds of gastritis." (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohnishi H,Asada M,Shichijo Y,Iijima N,Itabayashi E,Shimura K,Suzuki T,Yoshida S, Mine T.: "External radiotherapy for biliary decompression of hilor cholangiscarcinoma" Hepato-gastroenterol. 42. 265-268 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mine T,Yasuda H,Kataoka A,Nagasawa J,Takano T.: "Human chronic gastric ulcer and connexin" J.Clin Gastroenterol. 21. S104-S107 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mine T,Yasuda H,Akimoto K,Kataoka A, Mashima H, Tajima A,Fukujin H,Tuchida T, Takano T,Nagasawa T: "The effect of Iunsopragole treatment on the healing and relapse of peptic ulcer and serum levels of IgG with H.P. antibody" J.Clin Gastroenterol. 20. 575-578 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mashima H,Kanzaki N,Nobusawa R,You-QingZ, Suzuki M,Mine T,Kojima I.: "Derangement in the actinr-follistatin system in hepatoma cells." Gastroceterbgy. 108. 834-840 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohnishi H, Ogushi N,Tanaka S,Mogami H,Nobusawa R,Mashima H,Furukawa Mine T,Shimada O,Ishikawa H,Kojima I.: "Converson of amylase-secreting rat panaeatic AR42J cell neuron-like cells by acliri A." J.Cli. Invest. 95. 2304-2314 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kogure K,Omata W,Kanzaki N,You-Qing Z, Yasuda H,Mine T,Kojima I: "A single intraportal admimstration of folbstatin accelerates liver regeneration in partially hopote●●mized rats" Gastroenterology. 108. 1136-1142 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mine T, Akimoto K,Asano S,Kameda Y,Ueda F: "Elsevrei" Progress in Cell Research. 459 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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