• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of Digestion on Gastric and Pancreatic Secretion Regulated by Gastrointestinal Hormones

Research Project

Project/Area Number 07670621
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Women's Medical College

Principal Investigator

SHIRATORI Keiko  Tokyo Women's Medical College, Department of Medicine, Associatet Professor, 医学部, 助教授 (70101855)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordssecretin / cholecystokinin (CCK) / CCK receptor antagonist / gastrin / pancreatic secretion / gastric acid secretion / pancreatic islet / インスリン / CCK受容体 / 脂肪 / 胃液分泌 / 膵液分泌 / ガストリン / リパーゼ
Research Abstract

It has been well known that pancreatic enzymes have a most important role in the intestinal digestion, and gastric and pancreatic secretion is regulated by digestive products. We investigated the regulation of gastric and pancreatic secretion in response to intestinal nutrients (protein and fat) mediated by gastrointestinal hormones in rats.
1.Effect of intraduodenal fat (fat, lipase-digested fat, and fatty acid) on gastric acid secretion and gastrin release was studied. Although lipase-digested fat and fatty acid inhibited acid secretion and gastrin release, fat failed the inhibitory effect under diversion of pancreatic juice. It means that fat digestion by lipase is necessary for the inhibitory action of intraduodenal fat on gastric acid secretion.
2.Pancreatic stimulatory effect of intraduodenal long-and medium-chain trigyceride (LCT and MCT) was studied. Pancreatic secretion and CCK release was stimulated by LCT under pancreatic juice existed in the duodenum, but not affected by MCT.Under pancreatic juice diversion, LCT failed to stimulate pancreatic secretion. Thus, LCT digestion by pancreatic juice is necessary for stimulating pancreatic secretion.
3.Effect of intraduodenal protein (casein) and amino acids on pancreatic secretion and release of secretin and CCK was studied. Casein protein stimulated CCK release and enzyme secretion. On the other hand, amino acids stimulated secretin release and bicarbonate secretion. Thus, protein digestion affects hormone release and pancreatic secretion.
4.Intraduodenal administration of amino acids as well as fat, inhibited gastric acid secretion and gastrin release. The inhibitory action of amino acids was mediated by endogenous secretin released by amino acids.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Shimizu K,Shiratori K: "Effect of protein derivatives on pancreatic secretion and release of secretin and CCK in rats." American Journal of Physiology. 267. G508-G514 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shiratori K: "Effect of a novel and potent CCK-B receptor antagonist,YM022,ongastric and pancreatic secretion in vivo in rats." Gastroenterology. 108. A218- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikeda M,Shiratori K: "Intraduodenal amino acids inhibit gastric acid secretion and gastrin release mediated by secretin in rats." Gastroenterology. 110. A807- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Moriyoshi Y,Shiratori K: "Evaluation of CCK-A antagonistic acitivity of KSG504 and FK480 newly developed in Japan in the exocrine pancreas." Digestion. 57. 248-249 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shiratori K: "The physiological role of gastrin,CCK,and acetylcholine in gastric acid secretion in the gastric phase in rats." Regulatory Peptides. 64. 174- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岩部千佳,白鳥敬子: "膵外分泌調節因子としての内因性インスリンの役割に関する研究" 日本膵臓学会誌. 11. 360-367 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu K,Shiratori K,Watanabe S,Takeuchi T: "Effect of protein derivatives on pancreatic secretion and release of secretin and CCK in rats." American Journal of Physiology. 267. G508-G514 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shiratori K,Watanabe S,Moriyoshi Y: "Pancreatic juice-diversion augments oleic-acid stimulated pancreatic secretion and release of secretin and CCK in rats." Biomedical Research. 15 (Suppl.2). 387-389 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Moriyoshi Y,Shiratori K,Watanabe S: "Effect of a novel cholecystokinin receptor antagonist, FK480, administered intraduodenally, on pancreatic secretion in rats." Pancreas. 10 (3). 295-300 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shiratori K,Watanabe S,Shimizu K: "Effect of a novel and potent CCK-B receptor antagonist, YM022, on gastric and pancreatic secretion in vivo in rats." Gastroenterology. 108 (4). A218 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikeda M,Shiratori K,Shimizu K: "Intraduodenal amino acids inhibit gastric acid secretion and gastrin release mediated by secretin in rats." Gastroenterology. 110 (4). A807 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Moriyoshi Y,Shiratori K,Iwabe C: "Duration of anti-cholecystokinin (CCK) action on the rat exocrine pancreas of new CCK receptor antagonist, FK480, administered orally." Journal of Gastroenterology. 31 (2). 249-253 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Moriyoshi Y,Shiratori K: "Effect of chromostatin, a novel chromogranin A-derived peptide, on pancreatic exocrine secretion in rats." Gastroenterology. 110 (4). A1101 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu K,Kato Y,Shiratori K: "Cholecystokinin in rat pancreatic islet." Gastroenterology. 110 (4). A1119 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Moriyoshi Y,Shiratori K,Shimizu K: "Evaluation of CCK-A antagonistic acitivity of KSG504 and FK480 newly developed in Japan in the exocrine pancreas." Digestion. 64 (1-3). 174 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shiratori K,Shimizu K: "The physiological role of gastrin, CCK,and acetylcholine in gastric acid secretion in the gastric phase in rats." Regulatory Peptides. 57 (4). 248-249 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikeda M,Shiratori K: "Intraduodenal amino acids inhibit gastric acid secretion and gastrin release mediated by secretin in rats." Gastroenterology. 110. A807 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shiratori K: "The physiological role of gastrin,CCK,and acetylcholine in gastric acid secretion in the gastric phase in rats." Regulatory Peptides. 64. 174 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩部千佳,白鳥敬子: "膵内外分泌相関の基礎知識" 胆と膵. 16. 637-642 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Moriyoshi Y,Shiratori K: "Effect of a novel cholecystokinin receptor antagonist,FK480,administered intraduodenally,on pancreatic secretion in rats." Pancreas. 10. 295-300 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Moriyoshi Y,Shiratori K: "Duration of anti-cholecystokinin action on the rat exocrine pancreas of new CCK receptor antagonist FK480 administered orally." Journal of Gastroenterology. 31. 249-253 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩部千佳,白鳥敬子: "膵外分泌調節因子としての内因性インスリンの役割に関する研究." 日本膵臓学会誌. 11. 360-367 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shiratori K: "Pancreatic juice-diversion augments oleic acid-stimulated pancreatic secretion and release of secretin and CCK in rats." Biomedical Research. 15. 387-389 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白鳥敬子: "消化管ホルモン系負荷試験" ホルモンと臨床. 43. 103-110 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 白鳥敬子: "胃相における膵外分泌調節機構について" 日本膵臓学会誌. 10. 192 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shiratori K: "Effect of a novel and potent CCK-B receptor antagonist, YM022, on gastric and pancreatic secretion in vivo in rats." Gastroenterology. 108. A218 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 池田みどり,白鳥敬子: "セクレチン" 臨床検査. 38. 1153-1156 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shimizu K, Shiratori K: "Effect of Protein derivatives on pancreatic secretion and release of secretin and CCK in rats." American Journal of Physiology. 267. G508-G514 (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi