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Possibility of new endstopic pbotodynamic therapy with ultrasound.

Research Project

Project/Area Number 07670636
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionFukuoka University

Principal Investigator

TOMITA Akira  Fukuoka University, School of Medicine, Assisttant, 医学部, 助手 (20268999)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsphotodynamin therapy / Photofrin II / endoscopy / Ultrasound / colon 26 / 超音波 / 消化器癌
Research Abstract

Ultrasound has been used extensively over the last decades for medical diagnostics and physical therapy. Recently a number of reports have demonstrated enhanced cytotoxic responses when ultrasound and chemotherapeutic agents are combined.
Enhancement of acute cell killing of colon26 cells by low-level ultrasound in the presence of the photosensitizing drug Photofrin II was examined by the use of ultra-thin ultrasound probe in vitro. The probe has an outer diameter of 2 mm and fits through the instrument channel of a common endoscope. Photofrin II alone showed no significant cell killing effect but ultrasound alone showed a slight that. The combined ultrasound and Photofrin II showed marked cell killing effect.
These results suggest that the possiblity of the new endoscopic photodynamic therapy with ultrasound.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

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