| Project/Area Number |
07670696
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | University of Tokyo |
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Principal Investigator |
IWATSUBO Takeshi University of Tokyo Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (50223409)
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| Project Period (FY) |
1995 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Alzheimer's disease / beta-amyloid / 免疫細胞化学 / β蛋白 / ダウン症 / アミロイド |
|---|
| Research Abstract |
Deposition of beta-amyloid in senile plaques and in the walls of the cerebral vessels is the earliest pathological lesions in Alzheimer's disease and considered to be tightly associated with its pathogenesis. In this study, we established specific antibodies that recognize the heterogenous amino- and carboxyl-termini of amyloid beta protein (Abeta). We found (1) by immunocytochemistry that full-length Abeta42(43) as well as amino-terminally modified and truncated Abeta42(43) (i.e., those beginning at recemized or isomerized Asp 1 or pyroglutamate 3) deposit in diffuse plaques, and that (2) Abeta3pyroGlu-42(43) is the most predominant species that deposit in cerebral parenchyme as amyloid.
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