• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the Role of Aderrant Factor and Cardiac RAS for Activation of T cells in Myocardiac Infarction Transgenic Mouse

Research Project

Project/Area Number 07670743
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionHokkaido University

Principal Investigator

OKAMOTO Hiroshi  Hokkaido Univ., Medical Hospital, Assistant, 医学部・附属病院, 助手 (50260394)

Co-Investigator(Kenkyū-buntansha) KAWAGUCHI Hideaki  Hokkaido Univ., Fac.of Med., Professor, 医学部, 教授 (70161297)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordscardiac hypertrophy / renin-angiotensin system / transgenic mouse / heart failure / gene polymorphism / cardiomyopathic hamster / angiotensinogen / angiotensin-converting enzyme / 心筋梗塞 / T細胞 / オステオポンチン / 接着分子 / 心筋リモデリング / レニン-アンジオテンシン系
Research Abstract

The aim of this research project was to estabilish the transgenic mouse, which would be made by transfer renin-angiotensin system genes with cardiac specific promotor to mouse oocytes to clarify the tissue-specific role of genes of renin-angiotensin system in hte mechanism of cardiac hypertrophy. We have demonstrated that hypertrophic cardiomyopathy (HCM), especially in sporadic cases, is partially determined by genetic disposition and the molecular variant of angiotensin-converting enzyme D allele and angiotensinogen T235 seems to be a predisposing factor for cardiac hypertrophy. We have reported that in the experimental models of cardiac hypertrophy, gene expressions for renin, angiotensinogen, and angiotensin-converting enzyme were enhanced and signals leading to hypertrophy were processing through angiotensin type1 receptor and Gq coupling inositol phosphatide metabolism. We also obtained cardiac-specific promotor region of myosin to express the transfected gene within the heart. We have developed an adenovirus mediated gene transfer system, in which angiotensin-converting enzyme gene can easily transfected in vivo. Altough ther remain several steps to be overcome before making transgenic animal models of the renin-angiotensin system, these sophisticated studies provide original and important findings in the field of molecular cardiology.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Y.End-Mochizuki: "Expression of renin and angiotensin-converting enzyme in human hearts" Heart and Vessels. 10. 285-293 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Kawaguchi: "Phosphatidyl inositol and Inositol phasphatide metabolism in hypertrophic rat heart" Progress in Hypertension. 139-157 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Yoneya: "Angiotensin-converting enzyme gene polymorphism in Japanese patients with hypertrophic cardiomyopathy." Am Heart J. 130. 1089-1093 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Okada: "Alteration of extracellular matrix in dilated cardiomyopathic hamster heart" Moll Cell Biochem. 156. 9-15 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Watano et al.: "Nevrofibromatosis complicated with XXX syndrome and renovascular Hypertension" J Intern.Med. 239. 531-535 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishanov Alisher et al.: "Angiotensinogen Gene Polymorphism in Japanese patients with Hypertraphic Cardiomyopathy" Am Heart J. 133. 184-189 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Kawaguchi: "Heart hypertrophy and failure" Dhall Ns, 473 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Kawaguchi: "J Cardiac Failure" 512 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Endo-Mochizuki Y,Mochizuki N,Sawa H,Takada A,Okamoto H,Kawaguchi H,Nagashima K,Kitabatake A.: "Expression of renin and angiotensin-converting enzyme in human hearts." Heart and Vessels. 10. 285-293 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kawaguchi H,Akira Kitabatake.: "Phosphatydilinositol and Inositol Phosphatide Metabolism in Hypertrophic Rat Heart" Progress in Hypertension. 139-157 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoneya K,Okamoto H,Machida M,Onozuka H,Noguchi M,Mikami T,Kawaguchi H,Murakami M,Uede T,Kitabatake A.: "Angiotensin-Conveting Enzyme Gene Polymorphism in Japanese Patients With Hypertrophic Cardiomyopathy." Am Heart J. 130. 1089-1093 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okada H,Kawaguchi H,Kudo T,Sawa H,Okamoto H,Watanabe S,Urasawa K,Murakami T,Kitabatake A.: "Alteration of extracellular matrix in dilated cardiomyopathic hamster heart." Mol Cell Biochem. 156. 9-15 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Watano K,Okamoto H,Chika Takagi, Hisashi Mastuo H,Hirao N and Akira Kitabatake A.: "Neurofibromatosis Complicated with XXX Syndrome and Renovascular Hypertension." J Internal Med. 239. 531-535 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishanov A,Okamoto H,Yoneya K,Watanabe M,Nakagawa I,Onozuka H,Mikami T,Kawaguchi H,Hata A,KondoK,Kitabatake A.: "Angiotensinogen Gene polymorphism in Japanese patients with Hypertrophic cardiomyopathy." Am Heart J Machida M. 133. 184-189 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hideaki Kawaguchi, Akira Kitabatake.: "Altered Signal Transduction System in Hypertrophied Myocardium : Angiotensin II Stimulates Collagen Synthesis in Hypertrophied Hearts." J Cardiac Failure. 2. S13-S19 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hideaki Kawaguchi, Akira Kitabatake.: Heart Hypertrophy and Failure.Edited by Dhalla NS et., 473 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okada H.: "Alteration of Extracellular Matrix in dilated cardiomyopathic Hamster Heart." Moll Cell Biochem.156. 9-15 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Watano K.: "Neurofibromatosis Complicated with XXX Syndrome and Renovascular Hypertension" J Intern Med.239. 531-535 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawaguchi H.: "Renin-Angiotensin System in Failing Heart" J Moll. Cell Cardiol. 27. 201-209 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ishanov A.: "Angiotensinogen Gene Polymorphism in Japanese Patients with Hypertrophic Cardiomyopathy." Am Heart J. 133. 184-189 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoneya K: "Angiotensin-converting enzyme gene polymorphism in Japanese patients with hypertrophic cardiomyopathy." Am Heart J. 130. 1089-1093 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Endo-Mochizuki Y: "Expression of renin and angiotensin-converting enzyme in human hearts." Heart and Vessels. 10. 285-293 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okada H: "Alteration of extracellular matrix in dilated cardiomyopathic hamster heart." Mol Cell Biochem,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kawaguchi H: "Heart hypertrophy and failure" The alteration of signal transduction system in heart failure., 463-473. (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi