• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathophysiology of diastolic dysfunction in hypertrophied hearts-Role of myocyte cytoskeleton-

Research Project

Project/Area Number 07670789
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKYUSHU UNIVERSITY FACULTY OF MEDICINE

Principal Investigator

TSUTSUI Hiroyuki  KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ADJUNCT ASSISTANT PROFESSOR, 医学部, 講師 (70264017)

Co-Investigator(Kenkyū-buntansha) UENO Hikaru  KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (50260378)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsHypertrophy / Heart failure / Cytoskeleton / Microtubules / Viscosity / Elasticity / 肥大心 / 不全心 / 細胞骨格
Research Abstract

1) Role of microtubules for the myocyte contractile dysfunction during cardiac hypertrophy
The progressive increase of microtubule density during LV hypertrophy due to persistent pressure overloading to the myocardium may cause the consequent myocyte contractile dysfunction.
2) Role of microtubules in the viscoelastic properties of the myocardium
Microtubule alterations could also affect the contractile force development in the multicellular tissue preparations, which might allow us to extend the findings obtained at the cellular level to the ventricular contractile performance in vivo. The increased microtubules conld also contribute to the increased viscosity of the myocardium. Therefor, microtubules are of especial importance in cardiac muscle contractility because the alterations of these elements might well explain the performance changes noted in the hypertrophied myocardium.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Tagawa H, Rozich J, et al: "Basis for increased microtubules in pressure hypertrophied cardiocytes." Circulation. 93. 1230-1243 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishibashi Y, Tsutsui H, et al: "Role of microtubules for myocyte contractile dysfunction during cardiac hypertrophy in the rat." Am J Physiol. 271. H1978-1987 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takemoto M, Egashira K, et al: "Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide・・・" J Clin Invest. 99. 278-287 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsutsui H, et al: "Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy." Am J Physiol. 272. H168-H175 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamamoto S, Tsutsui H, et al: "Role of myocyte nitric oxide in β-adrenergic hyporesponsiveness in heart failure." Circulation. 95. 1111-1114 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Namba T, Tsutsui H, et al: "Regulation of fibrillar collagen gene expression and protein accumulation in volume overload cardiac hypertrophy" Circulation. 95. 2448-24564 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tagawa H,Rozich J,Tsutsui H,et al.: "Basis for increased microtubules in pressure hypertrophied cardiocytes" Circulation. 93. 1230-1243 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishibashi Y,Tsutsui H,et al.: "Role of microtubules for myocyte contractile dysfunction during cardiac hypertrophy in the rat." Am J Physiol. 271. H1978-1987 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takemoto M,Egashira K,Usiu M,Numaguchi K,Tomita H,Tsutsui H,et al.: "Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade on nitric oxide synthesis in rats." J Clin Invest. 99. 278-287 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsutsui H,et al.: "Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy." Am J Physiol. 272. H168-H175 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamamoto S,Tsutsui H,et al.: "Role of myocyte nitric oxide in beta-adrenergic hyporesponsiveness in heart failure." Circulation. 95. 1111-1114 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Namba T,Tsutsui H,et al.: "Regulation of fibrillar collagen gene expression and protein accumulation in volume overload cardiac hypertrophy." Circulation. 95. 2448-24564 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishibashi Y,Urabe Y,Tsutsui H,et al.: "Negative inotropic effect of basic fibroblast growth factor (bFGF) on adult rat cardiac myocyte." Circulation. 96. 2501-2504 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takahashi, M,Tsutsui H,et al.: "Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy." J Mol Cell Cardiol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishibashi Y,et al.: "Role of microtubules in myocyte contractile dysfunction during cardiac hypertrophy in the rat." Am J Physiol. 271. H1978-H1987 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takemoto M,et al.: "Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term" J Clin Invest. 99. 278-287 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsutsui H,et al.: "Alterations in sarcoplasmic reticlum calcium-storing proteins in pressure-overload cardiac hypertrophy." Am J Physiol. 272. H168-H175 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto S,et al.: "Role of myocyte nitroc oxide in β-adrenergic hyporesponsiveness in heart failure." Circulation. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Namba,T et al.: "Regulation of fibrillar collagen gene expression and protein accumulation in volume overload cardiac hypertrophy." Circulation. (in press). (1997)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi