| Project/Area Number |
07670794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
OGAWA Hisao Division of Cardiology, Kumamoto University School of Medicine, 医学部・附属病院, 講師 (50177135)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | adhesion molecule / Inter celullar Adhesion Molecule-1 (ICAM-1) / P-selectin / unstable angina / coronary artery spasm / P-selectin / 急性炎症 / Coronary Spasm / Myocardial Infarction / ICAM-1 / P-Selectin |
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| Research Abstract |
The Adhesion Molecules, Intercelullar Adhesion Molecule-1 (ICAM-1) and P-selectin, are related to the adherence of activated leukocytes on endothelial cells at the inflammatory process. We examined plasma levels of the soluble forms of ICAM-1 (sICAM-1) and P-selectin (sP-selectin) in the coronary sinus (CS) and aortic root (Ao) in the patients with ischemic heart disease. The mea value of CS and Ao were significantly higher in unstable angina than in stable exertional angina and in controls. Furthermore, in unstable angina the mean value was higher in CS than in Ao. It is suggested that sICAM-1 release is increased especially in coronary circulation in unstable angina. The plasma levels of the CS-Ao difference of sP-selectin were increased after left coronary artery spasm. They indicate that sP-selectin is released into the coronary circulation after coronary artery spasm. We conclude that the adhesion of leukocytes on the endothelial cell may occur in the coronary circulation in unstable angina and coronary artery spasm.
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