| Project/Area Number |
07670795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University School of Medicine |
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Principal Investigator |
YOSHIMURA Michihiro Cardiology, Kumamoto Univ.Sch.of Med.Instructor, 医学部・附属病院, 助手 (30264295)
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| Co-Investigator(Kenkyū-buntansha) |
YASUE Hirofumi Cardiology, Kumamoto Univ.Sch.of Med, Professor, 医学部, 教授 (40174502)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | A-type (atrial) natriuretic peptide / B-type (brain) natriuretic peptide / Heart failure / B型(脳性)カリウム利尿ペプチド / 心房性(A型)ナトリウム利尿ペプチド / 脳性(B型)ナトリウム利尿ペプチド |
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| Research Abstract |
A-type (atrial) natriuretic peptide and B-type (brain) natriuretic peptide (BNP) are novel cardiac peptides. The plasma levels of ANP and BNP are increased as heart failure advances. This study was performed to investigate the precise secretion patterns of ANP and BNP and the pathophysiological roles of ANP and BNP in heart failure. In the present study, we found that ANP is secreted mainly from the atria moreover also from the ventricles as heart failure advances. On the other hand, BNP is secreted mainly from the ventricles regardless of the severity of heart failure, suggesting the important dual natriuretic peptide system in heart failure. In the infarct ventricles, BNP especially increased from the adjoining site to the infarct area. ANP and BNP not only improve left ventricular function, but also may inhibit the ventricular remodeling after myocardial infarction. Thus, ANP and BNP have cardioprotective effect in heart failure. Further more, we found that BNP is secreted also in patients with unstable angina. The finding is important in the pathophysiology of ischemic heat disease. We examined the effects of the BNP infusion on systemic hemodynamic parameters and coronary circulation, too. These results suggest that ANP and BNP are involved in the pathophysiology of many cardiac disorders.
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