• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The significance of ACE gene polymorphism in ischemic heart disease

Research Project

Project/Area Number 07670801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionIwate Medical University

Principal Investigator

NAKAI Kenji  Iwate Medical Univ.Associate Prof., 医学部, 助教授 (90146035)

Co-Investigator(Kenkyū-buntansha) MIYAKAWA Tomohisa  Iwate Med.Univ.Assistant Porf., 医学部, 助手 (60254752)
AOKI Hidehiko  Iwate Medical Univ.Assistant Prof., 医学部, 講師 (10212375)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsanigotensin-I converting enzyme / gene polymorphism / myocardial infarction / late potential / remodeling / アンギオテンシン変換酵素 / 冠動脈疾患
Research Abstract

A difference with a Japanese and Westerners in a relation with a myocardial infarction (MI) and an angiotensin converting enzyme (ACE) gene polymorphism has not been fully elucidated. And a research in a Japanese with regard to relation between ACE gene polymorphism and the left ventricular remodeling after a MI are needed. We examined the significance of ACE gene polymorphism in the prognosis and the generation of left ventricular late potentials in healthy control and MI patients.
An ACE gene polymorphism was determined with PCR method in gathering DNA from a leukocyte. A presence of ventricular late potential was determined with an signal-averaged electrocardiogram. Also, a questionnaire survey by a letter was carried out. We analyzed a relation between ACE gene polymorphism and the presence of a cardiac events with Kaplan-Meier, and also analyzed the relation to left ventricular late potentials after the first MI.
[Results]1) ACE gene DD genotype could become a new coronary risk factor even Japanese ischemic heart disease (Circulation, 1995). 2) Total frequencies of cardiac events in low risk group (TC<260mg/dl, HbAlc<9.0%, BMI<26) after the first MI was 7 from 34 MI cases with ACE II genotype (20.6%), 15 from 71 MI cases with ACE ID genotype (21.1%), 21 from 58 MI cases with ACE DD genotype (36.2%). Kaplan-Meier analysis revealed that cardiac events in MI patients with ACE DD genotype were tendency to be increased than those in MI patients with ACE II and ID genotype (Musya T,Nakai K : J Iwate Med, 1997.in print). 3) A positive left ventricular late potentials increased the incidence in MI patients with an ACE DD genotype (Nakai K et al : A.N.E.1 : 405-410,1996).
We concluded that ACE DD genotype might relate to the genesis of cardiac events and left ventricular remodeling after the first MI in the Japanese.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Nakai K,et al.: "Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese." Circlation. 90. 2199-2202 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakai K,et al.: "A apolipoproteine 4 allele increased the risk for myocardial infarction among the Japanese carring the I allele of angiotensin I-converting enzyme gene polymorphism." Eur Heart J. 17. 563 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakai K,et al.: "Deletion polymorphism of the angiotensin I-converting enzyme gene associated with increased risk for late potentials in patients with myocardial infarction." A.N.E.I. 405-410 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 武者毅彦、中居賢司: "急性心筋梗塞症の発症と予後に関わるアンジオテンシン-I変換酵素遺伝子型の解析" 岩手医誌. (掲載予定). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakai K,Chuichi Itoh, Miura Y,et al.: "Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese." Circlation. 90. 2199-2202 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakai K,Shiroto T,Musya T,et al.: "A apolipoprotein epsilon4 allele increased the risk for myocardial infarction among the Japanese carring the I allele of angiotensin I-converting enzyme gene polymorphism." Eur Heart J. 17. 563 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakai K,Chiba N,Syobuzawa M,et al.: "Deletion polymorphism of the angiotensin I-converting enzyme gene associates with increased risk for late potentials in patients with myocardial infarction." A.N.E.1. 405-410 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Musha T,Nakai K.: "Deletion homozygotes of angiotensin-I converting enzyme gene incrased a risk for cardiac events after myocardial infarction." J Iwate med Ass. (Japanese, in print). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakai K,et al.: "A apolipoprotein e4 allele increased the risk for myocardial infarction among the Japanese carring the I allele of angiotensin I-converting enzyme gene polymorphism." Eur Heart J. 17. 563 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakai K,et al.: "Deletion polymorphism of the angiotensin I-converting enzyme gene associates with increased risk for late potentials in patients with myocardial infarction." A.N.E. 1. 405-410 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 武者毅彦、中居賢司: "急性心筋梗塞症の発症と予後に関わるアンジオテンシン-I変換酵素遺伝子型の解析" 岩手医誌. (掲載予定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakai K, et al: "Delection polymorphisim of the angiotensin I-converting enzyme gene associated with increased for late potential in myocardial infarction" Circulation. 92. I-741-I-742 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中居賢司、他: "アンギオテンシン変換酵素" 日本臨床. 53. 176-180 (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi