| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Research Abstract |
We detected the angiotensinogen gene variant (AA,Aa, aa) in 131 Japanese children using a polymerase chain reaction. We also measured height, weight, arm cicumference and blood pressure (BP), and set up a questionnaire concerning the life style and heredity for hypertension. Informed consent was obtained from parents to examine the blood chemistry and angiotensinogen gene variants.
The following results were obtained.
1) The genotype frequency of aa was 0.59, and the allele frequecy of a was 0.76. Genotype frequencies were not significantly different from Hardy-Weinberg's equilibrium in these Japanese children.
2) We found no significant relationship between the three genotypes (AA,Aa, aa) and either systolic or diastolic BP.
3) When comparing several variables in children with the aa genotype and the AA + Aa genotypes, systolic BP in children with aa was higher than in those with AA + Aa, although this was not statistically significant.
4) No relationship was found between children's BP and the family history of essential hypertension or their life style.
5) By multiple regression analysis, the genotype was a statistically significant independent factor of systolic BP.
Thsese findings suggest that this molecular variant of the angiotensinogen may play some role in the regulation of BP in Japanese children.
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