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Study on the risk of patiens with familial hypercholesterolemia by the determination of apolipoprotein E phenotyping

Research Project

Project/Area Number 07670845
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNiigata University

Principal Investigator

ASAMI Tadashi  Niigata University, School of Medicine, Associate Professor, 医学部, 助教授 (40018932)

Co-Investigator(Kenkyū-buntansha) KAKIHARA Toshio  Niigata University, School of Medicine, Assistant, 医学部, 助手 (70262433)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsfamilial hypercholesterolemia / apolipoprotein E / phenotype / アポE / フェノタイピング
Research Abstract

In familial hypercholelsterolemia (FH), the inter-individual variability in serum total cholesterol (TC) kevels raises a possibility that some still unknown factors, other than LDL receptors, may also contribute to them. Apolipoprotein E (apoE) is a plasma protein involved in cholesterol transport and metaboslim. The allelic variation in the apoE gene (E2/2, E2/3, E2/4, E3/3, E4/3, and E4/4.) is responsible for a proportion of the inter-individual variability in serum TC.With this background in mind, we investigated the association of apoE phenotypes with serum TC levels in FH children.
In 269 pediatric patients (hypercholesterolemia, hypothyroidism, malignant diseases, chance proteinuria and/or hematuria, renal diseases), apoE phenotypes were as follows ; E3/3 (192,71.6%), E4/3 (45,16.8%), E3/2 (24,9.0%), E5/3 (5,1.9%), and a very rare variant E7/4.The apoE phenotype of the 143 normal control subjects was E3/3 (100,70.0%) ; E4/3(29,20.4%) ; E3/2 (10,7.0%) ; and E4/2 and E5/3 (4,2.8%). Children with FH had no significant differences in each apoE phenotype distribution as comapared with the normal children. FH children without E4 allele had a tendency to respond cholesterol lowering therapy. In addition, obese children, with at least one E4 allele, had higher serum apoB levels, suggesting higher risk for future coronary atherosclerosis, and nephrotic children with at least one E4 allele were shown to be more steroid resistant.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Asami T, Kawasaki T, ほか: "A unique form of ricket with low serum 25-hydroxyvitamin D" Acta Paediatrica Japonica. 37. 182-188 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, Gomi T, et al: "Persistent non-familial asymptomatic hyperphosphatasemia:a report on three cases." Acta Paediatrica Int J Pead. 84. 346-348 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, Sakurai M: "Successful α-interferon therapy in a child with chronic refractory idiopathic thrombocytopenic purpura:a case report." Acta Paediatrica Japonica. 36. 75-77 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, Otabe N, et al: "A case of congenital hypothyroidism with delayed rise in serum TSH missed on newborn screening." Acta Pediatrica Japonica. 37. 634-637 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, Otabe N, et al: "Screening for neuroblastoma:a nine-year birth cohort-based study in Niigata,Japan." Acta Paed Int J Paed. 84. 1173-1176 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, Kikuchi T, et al: "Effects of L-thyroxine on serum lipid profiles in infants with congenital hypothyroidism." J Pediatr. 127. 812-814 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 浅見 直, 笹川 富士雄: "小児高脂血症の食事療法" The Lipid. 6. 149-156 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al.: "Study on proteinase inhibiting capacity of plasma α2-macroglobulin in idiopathic nephrotic syndrome." Nephron. 74・2. 512-517 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al.: "Serum carnitine concentrations in different glomerular diseases with normal renal function." Jap J Nephrology. 38・5. 229-232 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al.: "Effect of clonidine on the height of a child with glycogen storage disease type VI:A thirteen-year follow-up study." Acta Paed Jap. 38・5. 524-528 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al.: "Two families of Lowe oculocerebrorenal syndrom with elevated serum HDL cholesterol levels and CETP gene mutation." Acta Paed Int J Paed. 86・1. 41-45 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al.: "Incidence of febrile convusions in children with congenital hypothyroidism." Acta Paed. (印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al.: "Cholesterol levels in children with renal diseases." Pediatiric Nephrology. (印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Sakurai M: "Successful alpha-interferon therapy in a child with chronic refractoty idiopathic thrombocytopenic purpura : a case report." Acta Paediatrica Japonica. 36 (1). 75-77 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Kawasaki T,Sakai K: "A unique form of rickets with low serum 25-hydroxyvitamin D" Acta Paediatrica Japonica. 37 (2) (in press). 182-188 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Gomi T,Uchiyama M: "Persistent non-familial asymptomatic hyperphosphatasemia : a report on three cases" Acta Paediatrica Int J Paed. 84 (3). 346-348 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Otabe N,Wakabayashi M,Kikuchi T,Uchiyama M: "A case of congenital hypothyroidism with delayd rise in serum TSH missed on newborn screening" Acta Pediatrica Japonica. 37 (5). 634-637 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Otabe N,Wakabayashi M,Asami K,Kakihara T,Uchiyama M: "Screening for neuroblastoma : a nine-year birth cohort-based study in Niigata, Japan." Acta Paed Int J Paed. 84 (10). 1173-1176 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Kikuchi T,Uchiyama M: "Effects of L-thyroxine on serum lipid profiles in infants with congenital hypothyroidism" J Pediatr. 127 (5). 812-814 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Nishihara T,Tomisawa S,Sakai K,Uchiyama M: "Study on proteinase inhibiting capacity of plasma alpha2-macroglobulin in idiopathic nephrotic syndrome" Nephron. 72 (4). 512-517 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Yanagihara T,Tomisawa S,Hayakawa H,Uchiyama M: "Serum carnitine concentrations in different glomerular diseases with ormal renal function" Jap J Nephrology. 38 (5). 229-232 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Kikuchi T,Aikawa T,Asami K,Uchiyama M: "Effect of clonidine on the height of a child with glycogen storage disease type VI : A thirteen-year follow-up study" Acta Paed Jap. 38 (5). 524-528 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,Inano K,Miida T,Kikuchi T,Uchiyama M: "Two families of Lowe oculocerebrorenal syndrom with elevated serum HDL cholesterol levels and CETP gene mutation" Acta Paed Int J Paed. 86 (1). 41-45 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,et al.: "Incidence of febrile convusions in children with congenital hypothyroidism." Acta Paed. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T,et al.: "Cholesterol levels in children with renal diseases." Pediatiric Nephrology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Asami T, et al: "Incidence of febrile convusions in children with congenital hypothyroidism." Acta Paed. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asami T, et al.: "Cholesterol levels in children with renal diseases" Pediatiric Nephrology. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asami T,et al.: "Study on proteinase inhibiting capacity of plasma α2-macroglobulin in idiopathic nephrotic syndrome." Nephron. 74・2. 512-517 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Asami T,et al.: "Serum carnitine concentrations in different glomerular diseases with normal renal function." Jap J Nephrology. 38・5. 229-232 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Asami T,et al.: "Effect of clonidine on the height of a child with glycogen storage disease type VI : A thirteen-year follow-up study." Acta Paed Jap. 38・5. 524-528 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Asami T,et al.: "Two families of Lowe oculocerebrorenal syndrom with elevated serum HDL cholesterol levels and CETP gene mutation." Acta Paed Int J Paed. 86・1. 41-45 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Asami T,Kawasaki T.ほか: "A unique torm of rickets with low serum 25-hydroxyvitamin D." Acta Paediatrica Japonica. 37. 182-188 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Asami T, Gomi T, et al: "Persistent non-familial asymptomatic hyperphosphatasemia: a report on three cases." Acta Paediatrica Int Paed. 84. 346-348 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Asami T, Sakurai M: "Successful α-interferon therapy in a child with chronic refractory idiopathic thrombocytopenic purpura: a case report." Acta Paediatrica Japonica. 36. 75-77 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Asami T, Otabe N,et al: "A case of congenital hypothyroidism with delayed rise in serum TSH missed on nowbom screening." Acta Pediatrica Japonica. 37. 634-637 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Asami T, Otabe N,et al: "Screening for neuroblastoma: a nine-year birth cohort-based study in Niigata, Japan." Acta Paed Int J Paed. 84. 1173-1176 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Asami T,Kikuchi T, et al: "Effects of L-thyroxine on serum lipid profiles in infants with congenitel hypothy roidism." J Pediatr. 127. 812-814 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 浅見 直,笹川富士雄: "The Lipid 6" 小児高脂血症の食事療法., 149-156 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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