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Study on oncoimmunology in carrier children of HTLV-I

Research Project

Project/Area Number 07670880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKagoshima University

Principal Investigator

KAWAKAMI Kiyoshi  Kagoshima University, University Hospital, Assistant Professor, 医学部・附属病院, 講師 (50152921)

Co-Investigator(Kenkyū-buntansha) YOSHINAGA Mitsuhiro  Kagoshima University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (00221672)
HUJIYOSHI Toshinobu  Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50173480)
NAKAMURA Shigeyuki  Kagoshima University, University Hospital, Research Associate, 医学部・附属病院, 助手 (00295247)
北原 琢磨  鹿児島大学, 医学部, 助手 (90253880)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
KeywordsHTLV-I / mother-to-child / breast feeding / 抗腫瘍免疫 / 長期母乳哺育 / High HTLV-I antigen-producing mother
Research Abstract

We have investigated the transmission of human T-lymphotropic virus type I (HTLV-I) from mother-to-child for 12 years. The results are follows :
1)Transmission of HTLV-I from mother-to-child occurred with the rate of 4.9% in bottle feeders, and 8.0% in breast feeders. Among breast feeders, the rate of transmission was higher in the group of more than 7 months breast-fed children than in the group of less than 6 months brestfed children (25.0% vs 2.5%). There was statistically significant differences in the rate of trans-mission between the two groups.
2)Anti-HTLV-I antibody transmitted from mother, which have been detected by about 6 months after birth, was suggested to act as defensive against HTLV-I vertical infection.
3)The level of soluble interleukin-2 receptor was higher in the group of HTLV-I transmitted children than that in the group of non-transmitted children born to HTLV-I carrier mothers, and that in the group of normal control children. But no significant differences was admitted between the groups, due to small numbers of children tested in those groups.
4)Further investigations such as immunological studies against HTLV-I infection and human leukocyte antigens (HLA) among children born to HTLV-I carrier mothers are needed.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Mitsuhiro Yoshinaga: "A maternal risk factor for mother-to-child HTLV-I transmission:Viral antigen-producing capacities in culture of peripheral blood and breast milk cells." Japanese Journal of Cancer Research. 86. 649-654 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中村 茂行: "HTLV-Iと母子感染" 小児内科. 27(10). 1465-1468 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 嶽崎 俊郎: "母乳とウイルス感染-ATLウイルス感染-" 周産期医学. 26(4). 545-549 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中村 茂行: "HTLV-I感染症" 小児内科. 29. 879-881 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuhiro Yoshinaga, Shinji Yashiki, Toshitaka Oki, Toshinobu Fujiyoshi, Yukihiro Nagata, Shunro Sonoda: "A maternal risk factor for mother-to-child HTLV-I transmission : viral antigen-producing capacities in culture of peripheral blood and breast milk cells." Japanese Journal of Cancer Research. 86. 649-654 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shigeyuki Nakamura, Kiyoshi Kawakami: "HTLV-I and mother-to-child infection." Shoni Naika. 27(10). 1465-1468 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Toshiro Takezeki, Kiyoshi Kawakami, Mitsuko Ito, Ken-ichiro kinoshita, Kazuo Tajima: "Breast feeding and viral infectn-ATL virus infection." Shusanki Igaku. 26(4). 545-549 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shigeyuki Nakamura, Kiyoshi Kawakami: "HTLV-I infection." Shoni Naika. 29. 879-881 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 嶽崎 俊郎: "母乳とウイルス感染-ATLウイルス感染-" 周産期医学. 26(4). 545-549 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中村 茂行: "HTLV-I感染症" 小児内科. 29. 879-881 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中村茂行: "HTLV-Iと母子感染" 小児内科. 27(10). 1465-1468 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 嶽崎俊郎: "母乳とウイルス感染-ATLウイルス感染-" 周産期医学. 26(4). 545-549 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mitsuhiro Yoshinaga et al: "A Maternal Risk for Mother-to-Child HTLV-I Transmission:Viral Antigen-producing Capacities in Culture of Peripheral Blood and Breast Milk Cells." Japanese Journal of Cancer Research. 86. 649-654 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中村 茂行ら: "HTLV-Iと母子感染" 小児内科. 27. 73-76 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中村 茂行ら: "南九州におけるHTLV-I母児感染追跡調査報告書および陽転者の経時的PCRの推移" 母児感染研究論文集(HTLV-I母児感染研究会事務局発行). 6. 24-29 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 沖 利貴ら: "南九州におけるHTLV-I母児感染の実態調査-主に授乳期間と母児感染率-" 母児感染研究論文集(HTLV-I母児感染研究会事務局発行). 6. 43-48 (1994)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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