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ESTABLISHMENT OF "THEUMATIC CHRONIC FATIGUE SYNDROME IN CHILDREN" AND NATIONWIDE SURVEY OF ITS FREQUENCY

Research Project

Project/Area Number 07670885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionYOKOHAMA CITY UNIVERSITY

Principal Investigator

AIHARA Yukoh  YOKOHAMA CITY UNIV. SCH. OF MED., ASSISTANT PROFESSOR, 医学部・附属病院・小児科, 講師 (50211686)

Co-Investigator(Kenkyū-buntansha) YOKOTA Shumpei  YOKOHAMA CITY UNIV. SCH. OF MED., ASSISTANT PROFESSOR, 医学部・附属病院・小児科, 講師 (10158363)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsRHEUMATIC CHRONIC FATIGUE SYNDROME IN CHILDREN / ANTINUCLEAR ANTIBODY / DEFINITION
Research Abstract

WE ANALYZED 23 PATIENTS WITH "RHEUMATIC CHRONIC FATIGUE SYNDROME IN CHILDHOOD". FEMALE IS PREDOMINANT (91%), AND THERE WERE NO SPECIFIC CLINICAL SYMPTOMS. HOWEVER, FEVER (61%), ARTHRALGIA (57%), GENERAL FATIGUE (48%) AND HEADACHE (35%) WERE FREQUENTLY OBSERVED. AS FOR LABORATORY DATA, ALL PATIENTS HAVE ANTlNUCLEAR ANTIBODY(ANA) WITH LOW TITER (1:40-1:640) IN SERA. THE FLUORESCENT PATTERN OF ANAS IN ALL BUT ONE (96%) WERE HOMOGENEOUS/SPECKLED. IN SOME PATIENTS, RHEUMATOID FACTOR, HYPERGAMMAGLOBULINEMIA AND ACCELERATION OF ESR WERE OBSERVED. OTHER AUTOIMMUNE ANTIBODIES WERE NOT DETECTED IN MOST PATIENTS. THE LEVELS OF SERUM COMPLEMENT, ELECTROENCEPHALOGRAM AND PSYCHOLOGICAL ANALYSIS WERE NORMAL.
FAMILY STUDY REVEALED THAT 55% OF THEIR MOTHERS HAD SIMILARLY LOW TITER (1:40-1:80) OF ANA IN SERA. THE FLUORESCENT PATTERNS OF ANAS WERE ALL HOMOGENEOUS/SPECKLED. SOME OF THEM HAD THE SAME SYMPTOMS OF THE PATIENT.
FROM THE ANALYSIS OF ANTIGENS RECOGNIZED BY ANAS IN PATIENTS, SO FAR WE COULD NOT DETECT ANY SPECIFIC BANDS COMMONLY SEEN IN THE PATIENTS WITH IMMUNOBLOTTlNG.
WE HAVE FINISHED THE ANALYSIS OF CLINICAL SYMPTOMS AND LABORATORY DATA COMMONLY USED IN CLINIC IN THE PATIENTS. HOWEVER, WE STILL HAVE BEEN TRYING TO FIND OUT SPECIFIC MAKERS IN ANA AND TO ESTABLISH NEW DEFINITIONS OF THIS SYNDROME. IN PRELIMINARY STUDY, THERE WERE NOT A FEW PATIENTS FITTED WITH THE SYMPTOMS AND LABORATORY DATA MENTIONED ABOVE.
IN NEAR FUTURE WE WILL DO A NATION-WIDE SURVEY OF THIS SYNDROME WITH THE NEWLY ESTABLISHED DEFINITION.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 友野順章、栗山智之、森雅亮、高橋由利子、満田年宏、相原雄幸、横田俊平: "小児期発症進行性全身性硬化症におけるRaynaud現象の経時的サーモグラフィー所見"リウマチ. 36. 522-527 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 横田俊平、今川智之、森雅亮、満田年宏、相原雄幸: "小児期発症混合性結合組織病 -全国調査の結果から-"日本内科学会誌. 85. 1217-1222 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 横田俊平、今川智之、相原雄幸: "小児期発症混合性結合組織病の全国調査結果 (1)臨床症状についての解析 (2)治療法についての解析"厚生省特定疾患 混合性結合組織病調査研究班 平成7年度研究報告書. 53-59 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 相原雄幸、森雅亮、友野順章、今川智之、片倉茂樹、高橋由利子、満田年宏、横田俊平: "感染症罹患に伴い抗核抗体が検出された5症例の臨床的検討"小児感染免疫. 9. 115-120 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Aihara,C.Shimizu,Y.Fujiwara,S.Yokota: "Acute anterior in a child with HLA-B60 after salmonella enteritis associated with transient appearance of auto-antibody"Acta Paediatrica Japonica. 38. 286-287 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Yokota,T.Imagawa,S.Katakura,S.itoh,T.Mitsuda,S.Fujikawa,Y.Aihara: "Mixed connective tissue disease in childhood : A nationwide retrospective study in Japan"Acta Paediatrica Japonica. 39. 273-276 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Aihara,M.Mori,T.Kobayashi,S.Yokota: "A pediatric case of polymyositis associated with Mycoplasma pneumoniae infection"Scand J Rheumatol. 26. 480-481 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 相原雄幸: "抗核抗体"小児内科. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.TOMONO, T.KURIYAMA, M.MORI, Y.TAKAHASHI, T.MITSUDA, Y.AIHARA, S.YOKOTA: "SERIAL COMPUTED THERMOGRAPHY FOR RAYNAUD'SPHENOMENON OF PATIENT WITH PROGRESSIVE SYSTEMIC SCLEROSIS (PSS)"RYUMACHI. 36(IN JAPANESE). 522-527 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.YOKOTA, T.IMAGAWA, M.MORI, T.MITSUDA, Y.AIHARA: "MIXED CONNECTIVE TISSUE DISEASE IN CHILDHOOD: A NATIONWIDE RETROSPECTIVE STUDY IN JAPAN"JJM. 85(IN JAPANESE). 1217-1222 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.AIHARA, M.MORI, M.TOMONO, T.IMAGAWA, S.KATAKURA, Y.TAKAHASHI, T.MITSUDA, S.YOKOTA: "CLINICAL STUDY OF THE PATIENTS WITH COMMON INFECTIOUS DISEASES, WHO SHOWED ANTINUCLEAR ANTIBODY IN SERA"JJII. 9(IN JAPANESE). 115-120 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Aihara, C.Shimizu, Y.Fujiwara, S.Yokota: "Acute anterior uveitis in a child with HLA-B60 after Salmonella enteritis associated with the transient appearance of auto-antibody"Acta Paediatrica Japonica. 38. 286-287 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Yokota, T.Imagawa, S.Katakura, S.Itoh, T.Mitsuda, S.Fujikawa, Y.Aihara: "Mixed connective tissue disease in childhood: A nationwide retrospective study in Japan"Acta Paediatrica Japonica. 39. 273-276 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Aihara, M.Mori, T.Kobayashi, S.Yokota: "A pediatric case of polymyositis associated with Mycoplasma pneumoniae infection"Scand J Rheumatol. 26. 480-481 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.AIHARA: "ANTINUCLEAR ANTIBODY"JPM. (IN PRESS).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yukoh Aihara et al: "Acute anterior uveitis in a child with HLA-B60 after Salmonella urteritis associated with the transient appearance of auto-antibody" Acta Paediatrics Japonica. 38. 286-287 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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