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Plasma endothelin and metabolites of nitric oxide in the pulmonary vein in the patients with pulmonary hypertension

Research Project

Project/Area Number 07670919
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKansai Medical University

Principal Investigator

TERAGUCHI Masayuki  Kansai Medical University, Department of Pediatrics, Research Associate, 医学部, 助手 (50257937)

Co-Investigator(Kenkyū-buntansha) TAKAYA Junji  Kansai Medical University, Department of Pediatrics, Research Associate, 医学部, 助手 (80247923)
IKEMOTO Yumiko  Kansai Medical University, Department of Pediatrics, Research Associate, 医学部, 助手 (50278610)
OGINO Hirotaro  Kansai Medical University, Department of Pediatrics, Assistant Professor, 医学部, 講師 (40131429)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
KeywordsCongenital Heart Disease / Pulmonary Hypertension / Endothelin / Nitric Oxide / エンドセリン(ET) / 一酸化窒素代謝物(NOx) / 肺動脈圧 / 心臓カテーテル検査
Research Abstract

Pulmonary vascular tone is regulated by multiple mediators. Among these factors, endothelin (ET) is the most potent vasoconstrictor, and nitric oxide (NO) is a potent vasodilating factor. The purpose of this study is to evaluate the physiological significance of both NO and ET in pulmonary hypertension associated with congenital heart diseases.
A total of 50 patients (age, 7months to 13 years) with congenital heart diseases (VSD,ASD,PDA,valvular PS,and TOF) were studied during cardiac catheterization. Blood samples were obtained from the main pulmonary artery and left ventricle. We measured metabolites of NO (NO<@D2X@>D2) by using high power liquid chromatography and ET-1 by radioimmunoassay. Nineteen patients with pulmonary hypertension [PH group : mean pulmonary artery pressure (MPAP), 30(]SY+-[)10 mmHg] were compared with 31 patients without pulmonary hypertension (non-PH group : MPAP,15(]SY+-[)3 mmHg). Plasma ET levels were significantly higher in the PH group (3.4(]SY+-[)2.0pg/ml, … More p<0.01) than in the non-PH group (1.6(]SY+-[)0.7 pg/ml). Plasma NO<@D2X@>D2 levels were also significantly higher in the PH group (2.4(]SY+-[)1.1 ppm, P<0.01) than in the non-PH group (1.6(]SY+-[)0.7 ppm). There was a significant correlation between plasma NO<@D2X@>D2 levels and MPAP (r=0.42, P<0.01). Plasma ET levels were also correlated with MPAP (r=0.4, P<0.01). In the PH group, plasma ET showed a positive correlation with the ratio of pulmonary to systemic blood flow (Qp/Qs) (r=0.68, P<0.01), although plasma NO<@D2X@>D2 levels showed no correlation with Qp/Qs. Moreover in this group, plasma NO<@D2X@>D2 showed a significant correlation with pulmonary vascular resistance (r=0.55, P<0.05). Among the 10 postoperative cases, plasma NO<@D2X@>D2 levels were siginificantly higher in the PH group (3.1(]SY+-[)1.3 ppm, p<0.05) than in the non-PH group (1.4(]SY+-[)0.6 ppm), although plasma ET-1 levels showed no significant difference between the both groups.
We concluded that plasma levels of ET-1 and NO were elevated in pulmonary hypertension. Elevated levels of ET-1 were related to increased pulmonary blood flow and the secretion of NO might be stimulated by the increase of pulmonary vascular resistance. Both of them a different role in the modulation of pulmonary hypertention. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Masayuki Teraguchi: "Multiple hepatoblastomas associated with trisomy 18 in a 3-year-old girl" Pediatric Hematology and Oncology. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yumiko Ikemoto: "Early changes in plasma brain and aterial natriuretic peptide in premature infants : correlation with pulmonary arterial pressure" Earlly Human Development. 46. 55-62 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Nogi: "Direct Transaortic Balloon Valvuloplasty under Cardiopulmonary Bypass for Neonatal Critical Aortic Stenosis" Cardio Vascular and Interventional Radiology. 19. 374-376 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 荻野廣太郎: "川崎病における^<123>I-metaiodobenzylguanidine(MIBG)心筋イメージングの検討" 日本小児循環器学会雑誌. 12.1. 16-24 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masayuki Teraguchi: "Multiple hepatoblastomas associated with trisomy 18 in a 3-year-old girl" Pediatric Hematology and Oncology. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yumiko Ikemoto: "Early changes in plasma brain and aterial natriuretic peptide in premature infants correlation with pulmonary arterial pressure" Earlly Human Development. 46. 55-62 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shunji Nogi: "Direct transaortic balloon valvuloplasty under cardiopulmonary bypass for neonatal critical aortic stenosis" Cardio Vascular and Interventional Radiology. 19. 374-376 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masayuki Teraguchi: "Multiple hepatoblastomas associated with trisomy 18 in a 3-year-old girl" Pediatric Hematology and Oncology. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yumiko Ikemoto: "Early changes in plasma brain and aterial natriuretic peptide in premature infants : correlation with pulmonary arterial pressure" Earlly Human Development. 46. 55-62 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shunji Nogi: "Direct Transaortic Balloon Valvuloplasty under Cardiopulmonary Bypass for Neonatal Critical Aortic Stenosis" Cardio Vascular and Interventional Radiology. 19. 374-376 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 荻野廣太郎: "川崎病における^<123>I-metaiodobenzylguanidine(MIBG)心筋イメージングの検討" 日本小児循環器学会雑誌. 12・1. 16-24 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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