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Analysis of autoantibody induced by metal antigens

Research Project

Project/Area Number 07670959
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionYokohama City University

Principal Investigator

ISHII Norihisa  YOKOHAMA CITY UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (50159670)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsAutoantibody / Delayd-type hypersensitivity (DTH) / Genetic control / Gold / Major histocompatibility complex (MHC) / Mercury / Metal antigen / Mouse / 遅延型反応
Research Abstract

The genetic control of delayd-type hypersensitivity (DTH) to both gold (I) and gold (III) antigens was investigated in various strains of mice. Most mouse strains, with the exception of those with the major histocompatibility complex I-A^b allele, showed a marked DTH response to each antigen ; the magnitude of the response to gold (III) was greater than that of the response to gold (I). Moreover, the high responsive trait was dominant. The DTH footpad response was mediated by CD4^+8^-, Ia^-T cells.However, CD8^+T cells did not suppress footpad swelling. These results indicate that gold (I) and gold (III) can both stimulate a DTH response in mice.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 石井則久: "ニッケル皮膚炎" 日本皮膚科学会雑誌. 106. 1701-1702 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 石井則久: "Genetic control of delayed-type hypersensitivity to gold antigens in mice." Journal of Dermatological Science. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nirohisa Ishii: "Nickel dermatitis" Japanese Journal of Dermatology. 106. 1701-1702 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nirihisa Ishii, Kazuo Takahashi, Mamiko Ishiwa, Yasuyuki Sugita, Hiroshi Nakajima: "Genetic control of delayd-type hypersensitivity to gold antigens in mice" Journal of Dermatological Science. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 石井則久: "ニッケル皮膚炎" 日本皮膚科学会雑誌. 106. 1701-1702 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 石井則久: "Genetic control of delayed-type hypersensitivity to gold antigens in mice." Journal Dermatological Science. (in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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