Enhancement of skeletal uptake of bone seeking agents in rat models by dietary manipulation.
| Project/Area Number |
07670985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
SETO Hikaru Faculty of medicine, TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Professor, 医学部, 教授 (20019962)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Masatoshi Faculty of Medicine, TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Assistant, 医学部, 教務職員 (30143861)
KAGEYAMA Masanari Faculty of Medicine, TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Assistant, 医学部, 助手 (70240778)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | internal radidtion therapy / bone-seeking agent / skeretal uptake / enhancement / Ca-47 chloride / Tc-99m MDP / Sr-89 Chloride / Sm-153 EDTMP / Ca-47chloride / Sr-89chloride / Sm-153EDTMP / オートラジオグラフィ / 放射性薬剤 / 定量化 |
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| Research Abstract |
The use bone-seeking agents, such as the calcium analogue, strontium-89 chloride, or the radiolabeled phosphate compound, samarium-158 EDTMP provides effective means of dilivering systemic radiation therapy for osseous metastases. Bone marrow depression, however, remains a main side effect. Enhancement of skeletal uptake is, therefore, required. The purpose of this study is to enhance the skeletal uptake of these radiopharmaceuticals in rat models by dietary manipulation.
Eight-week-old male Wistar rats (n=18) were housed for two weeks. Three models with different bone metabolism were established by means of dietary manipulation ; normal control (C), low-calcium group (A), and low-phosphate group (B). Ca-47 chloride and Tc-99mMDP were injected at the second week and 24-h global skeletal uptake (GSU) was measured for Tc-99m and Ca-47, respectively. Rats were, then sacrificed. Each femur was weighed and counted for Ca-47. The values for 24-h GSU (%) of Tc-99m MDP were as follows ; C group : 51.7 (]SY.+-。[) 2.7, A group : 49.6 (]SY.+-。[) 3.5, B group : 69.3 (]SY.+-。[) 5.6 (p<0.01). The values for 24-h GSU (%) of Ca-47 chloride were as follows ; C group : 80.2 (]SY.+-。[) 2.7 A group : 93.7 (]SY.+-。[) 3.1 (p<0.01), B group : 72.3 (]SY.+-。[) 4.3 (p<0.01). The values for femoral uptake (% dose/g) of Ca-47 were as follows : C group : 3.76 (]SY.+-。[) 0.33, A group : 4.27 (]SY.+-。[) 0.15 (p<0.01), B group : 3.09 (]SY.+-。[) 0.18 (p<0.01). In conclusion, a 34.0% increase in GSU of Ca-47 in the low-calcium group were observed. Enhancement of skeletal uptake of Tc-99m MDP and Ca-47 chloride was archived by the dietary manipulation.
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Report
(3 results)
Research Products
(6 results)
