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A Trial Of Differentiating Hepatocellular Carcinoma From Analogous Lesions In Rat Experimental Tumor Models Using Iron Colloid Enhanced MR Imaging.

Research Project

Project/Area Number 07671004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTottori University

Principal Investigator

SUTO Yuji  Tottori University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (10135858)

Co-Investigator(Kenkyū-buntansha) KATO Takashi  Tottori University, University Hospital of Faculty of Medicine, Research Associa, 医学部附属病院, 助手 (70194826)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1995: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsMRI / Liver / Contrast Agent / Iron collid / Animal / Autoradiography / Cancer
Research Abstract

To demonstrate the usefulness of iron colloid-enhanced MR images (MRI) in differentiating between hepatocellular carcinoma (HCC) and hyperplastic nodular lesions (HN), microautoradiograms were prepared after administration of chondroitin sulfate iron colloid (CSIC) labelled with 59Fe in rat tumor models. Twenty rats were divided into 3 groups, normal, HCC and HN groups. In the HCC,0.06% 3'-Mmethydiaminobenzine tetrahydro-chloride (DAB) was administered for 3 consecutive months for tumor induction. In the HN,0.025% acetylaminofluorene (AAF) was intermittently administered for 4 months. HCC models were divided into 2 types, well-differentiated HCC (HCC-W), moderately to poorly-differentiated HCC (HCC-MP). By quantitative analysis using microautoradiography, the number of Kupffer cells per field of view was calculated. Furthermore, the images on the dark fields were transferred to an image processing system. A photosensitized area ratio (PAR) was calculated. These ratios were compared among groups.
There was no significant difference in either the number of Kupffer cells or PAR between HN and normal liver tissues. In HCC-W,Kupffer cells were also present. However, their distribution was scattered, and the number of Kupffer cells and the PAR were significantly lower than those in normal liver tissues. In HCC-MP,the distribution of Kupffer cells was also scattered. Both the number of Kupffer cells and the PAR were significantly lower than those in HCC-W.
In conclusion, iron colloid-enhanced MRI is useful for differentiating HCC from HN and diagnosing the degree of differentiation of HCC.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Yuji Suto: "Usefulness of iron colloid-enhanced MRI in differentiating experimental hepatocellular carcinoma from hyperplastic nodule in rats : analysis by microautoradiography." Br J Radiol. 69. 1139-1144 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] YUJI SUTO: "Usefulness of Iron Collid-Enhanced MRI in Differentiating Experimental Hepatocellular Carcinoma from Hyperplastic Nodule in Rats : Analysis by Microautoradiography" Br J Radiol. 69-12. 1139-1144 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yuji Suto: "Usefulness of iron colloid-enhanced MRI in differentiating experimental hepatocellular carcinoma from hyperplastic nodule in rats:analysis by microautoradiography." Br J Radiol. 69・12. 1139-1144 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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