| Project/Area Number |
07671007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tokushima |
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Principal Investigator |
YOSHIDA Syusaku The University of Tokushima, Department of Radiology, Associate professor, 医学部, 助教授 (20136261)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Nobuya The University of Tokushima, 2nd Department of Pathology, Associate professor, 医学部, 助教授 (90196303)
MUKAIJO Toshifumi The University of Tokushima, Hospital, Department of Radiology, Research Associa, 医学部・付属病院, 助手 (90190842)
MATSUZAKI Kenji The University of Tokushima, Department of Radiology, Research Associate, 医学部, 助手 (70274222)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Hepatocellular Carcinoma (HCC) / Magnetic Resonance Imaging (MRI) / Histopathology / Borderline Lesion / Copper / Iron / Cellularity / Fat / 核磁気共鳴画像(MRI) / 早期境界病変 / 病理組織等 |
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| Research Abstract |
The histopathologic factors which may influence the signal intensity patterns of MRI were evaluated to clarify the causes of characteristic hyperintense pattern of well differentiated hepatocellular carcinoma and borderline lesions such as adenomatous hyperplasia on T1-weighted images of MRI.
Fatty metamorphosis was proved to be one of the causes and demonstrated by using the fat saturated images. Higher sensitivity of MRI compared to CT was also demonstrated.
The paramagnetic effect of copper accumulation was concluded to be insufficient to influence the MRI.Iron accumulation was suggested to be one of the causes and additional gradient echo sequences may improve the detectability of borderline lesions and may be helpful for the evaluation of histological grades.
We also suggested that the increased cellularity might increase the signal intensity and pointed out the similarity between borderline lesions and benign hyperplastic lesions on both imaging and histology which supported this hypothesis.
The causes of characteristic hypointence pottern of well differentiated hepatocellular carcinoma and borderline lesions on T2-weighted images were also examined histopathologically. We suggested the relative hypointense pattern of such lesions resulted from increased signal intensity of surrounding parenchyma caused by the inflammation associated with chronic hepatic disease.
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