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Improved Visualization of Hypercutete Cerebral Intartion with Magnetization Transfer Contrast : Phantom and Animal Study

Research Project

Project/Area Number 07671018
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

KOROGI Yukunori  Kumamoto University School of Medicine, Associate Professer, 医学部, 助教授 (60195691)

Co-Investigator(Kenkyū-buntansha) URATA Joji  Kumamoto University Hospital, Assistant professor, 医学部・附属病院, 助手 (30264302)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsMagnetization transfer contrast / Magnetic resonance imaging / high magnetic field / hyperacute cerebral infarction
Research Abstract

The magnetization transfer contrast (MTC) is a relatively new technique to generate additional tissue contrast. The purpose of this study was to evaluate the effectiveness of MTC technique in experimental hyperacute brain ischemia after Gd-DTPA administration at 7 T.
In the preliminary study, we investigated optimal combinations of the wave type, duration, amplitude, and offset frequency of MTC pulse in vitro. The optimal MTC pulse was the gauss pulse with longer duration, maximal amplitude and approximately 3 kHz off resonance. In 7 T MR system the signal intensity reduction with MTC pulse cannot be avoided.
In the animal study, MTC pulse used was a 20 msec gauss pulse, the amplitude of 12.6muT,and the offset frequency of 1 kHz. Mongolian gerbils after temporarily occlusion of common carotid artery were administrated intravenously with 0.2 mmol/kg of Gd-DTPA and the T1-weighted images without and with the MTC pulse were obtained.
No abnormal enhancements were observed in the control group without carotid occlusion. In the group with 30 minutes of bilateral temporary occlusion, the contrast enhanced T1-weighted images showed abnormal enhancement around the bilateral ventricles after one hour from carotid occlusion. Contrast between the enhancing area and the normal brian tissues was improved with MTC pulse, although the moderately signal intensity reduction was observed. In the group with 3 hours of unilateral occlusion, abnormal enhancement was also observed around the lateral ventricle dominantly in temporarily occluded side. As time passed, the area of abnormal contrast enhancement began to spread in the basal ganglia. The enhancement of basal ganglia was more conspicuous with application of the MTC pulse.
MTC technique and Gd-DTPA can synergistically improve the depiction of hyperacute brain ischemia.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Satoshi Hamatake: "Determination of the Optimal Pulses in MR Imaging with Magnetization Transfer Contrast at 7 Tesla." Radiation Medicine. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hamatake: "Determination of the Optimal Pulses in MR Imaging with Magnetization Transfer Contrast at 7 Tesla." Radiation Medicine. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary

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Published: 1995-04-01   Modified: 2016-04-21  

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