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(An Experimental Study on Retreavable Tracheobronchial Stent Graft with High Affinity)

Research Project

Project/Area Number 07671024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionWAKAYAMA MEDICAL COLLEGE

Principal Investigator

SONOMURA Tetsuo (1997)  Wakayama Medical College, Fellow, 医学部, 助手 (60264892)

岸 和史 (1995-1996)  和歌山県立医科大学, 医学部, 講師 (70254547)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Hisashi  Wakayama Medical College, Associate Professor, 医学部, 講師
TERADA Masaki  Wakayama Medical College, Associate Professor, 医学部, 講師 (80188680)
SATO Morio  Wakayama Medical College, Professor, 医学部, 教授 (50154109)
KISHI Kazushi  Wakayama Medical College, Associate Professor (70254547)
藤本 尚 (山林 尚)  和歌山県立医科大学, 医学部, 助手 (10186760)
木村 誠志  和歌山県立医科大学, 医学部, 助手 (60254546)
園村 哲郎  和歌山県立医科大学, 医学部, 助手 (60264892)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsStent / Tracheobronchial stenosis / Dacron / Nitinol / Stenless steel / Complication / Polyurethane / Polyethylene / 気管気管支狭窄 / ステント / 動物実験 / ニチノール / ポリウレタン / ポリエチレン / ビ-グル犬 / ニチノール(Nitinol) / polyethylene
Research Abstract

Purpose : To elucidate and compare histocompatibility of the tracheal stents by animal experiments.
Materials and Methods. Twelve beagle dogs underwent tracheal stent implantation. Bare Z-stents (BZ), Dacron covered z-stents (DCZ), Polyurethane coated Dacron covered Z-stents (PUZ), Polyethylene mesh stents (PEM), and Nitinol knitted stents (NKT). The stents were deployed in the trachea or main stem bronchus under general anesthesia and endoscopic guidance. Radiogram was taken immediately after and monthly endoscopic examination was performed. Dying animals immediately, and half of the alive at the seventh month, were sacrificed for histologic examination.
Results. For the first two months there were no abnormality in bronchoscopic findings. However at the third month a conspicious granulation, hyperplasia of mucosa and ulnceration ocurred in Bare Z-stent group. The stents were firmly involved in the tissue ingrowth. Similar but lighter findings were observed in the bare portion of DCZ and PUZ groups. Such granulamatous ingrowth was hardly found in the PEM and covered portion of the DCZ and PUZ.A bulge of glanuroma was found at the distal end of PEM.Most of NTK was patent. There was dying or dead animals in BZ, PUZ, at the third month due to or related to the tracheal stenosis, and at the fifth month The other BZ, DCZ, PEM.At the seventh month the alives were o/2 of BZ, o/2 of DCZ, 1/2 of PUZ, 3/4 of PEM, and 2/2 of NTK.All stented region showed narrowing by granulation tissue ingrowth.
Conclusion : From results of this beagle experiment all type of endotracheal stents were patent for the first two months and have glanuration tissue or (sub)mucosal hyperplasia, within seven months. In the decreasing order of frequency of granulation, NTK, PEM, PUZ, DCZ, and BZ.The granulation reaction speculatively came from mechanical irritation and stents shoud have more sophisticated structure, otherwize, effective and safe countermeasure should be devised to these reactions.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 岸 和史,他: "気管気管支狭窄症治療のための再撤去可能生体適合自己各庁型ステントの開発" innervision. 8. 10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kishi K,etc: "A Dedicated Z-stent for acquired saber-sheath thacheobronchomalacia" Cardiovascular and Interventional Radiology. 20. 462-465 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岸 和史: "胸部進行悪性腫瘍のステント治療と放射線治療" 治療学. 31. 9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岸 和史 他: "食道と気管気管支に対する金属ステント治療" 医学のあゆみ. 180. 11 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岸 和史,他: "肺癌、食道癌におけるIVRと放射線治療、進行胸部悪性腫瘍による上大静脈、気管気管支、食道狭窄のstent治療と放射線治療の臨床的比較検討" 臨床放射線. 43. 657-665 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura Y,etc: "Left postpneumonectony syndrome successfully treated with endobronchial stent." Internal Medicine. 37. 880-883 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kishi K,etc: "Endotracheobronchial stent placement of complicated esophagorespiratory fistula i a preliminary clinical expcrience." Cardiovascular and Interventional Radiology. (in progress).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岸 和史 他: "「Metallic Stentの現状と進歩[1]」第12・13回 Metallic Stent研究会編" 部分被覆型Z-ステントの作業と方向の制御方法について, 250 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Kishi et al.: "An Experimental Study on Retreavable Tracheobronchial Stent Graft with High Affinity" Innervision. 11. 10 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] KISHI K, FUJIMITO HK, ET AL.: "A DEDICATED Z-STENT FOR ACQUIRED SABER-SHEATH TRACHEOBRONCHO-MALACIA" CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. 20. 462-465 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K KISHI, ET AL.: "RATIONALE AND CLINICAL EFFECTS OF STENT THERAPY TO SUPERIOR VENA CAVA SYNDROME, TRACHEOBRONCHIAL STENOSIS, AND ESOPHAGEAL STENOSIS OR FISTULA DUE TO MALIGNANT TUMOR" JAPANESE JOURNAL OF CLINIVAL RADIOLOGY. 43. 657-665 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y NAKAMURA ET AL.: "LEFT POSTPNEUMONECTOMY SYNDROME SUCCESSFULLY TREATED WITH ENDOBRONCHIAL STENT" INTERNAL MEDICINE. 37. 880-883 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K KISHI ET AL.: "ENDOTRACHEOBRONCHIAL STENT PLACEMENT OF COMPLICATED ESOPHAGORESPIRATORY FISTULA ; A PRELIMINARY CLINICAL EXPERIENCE" CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. (IN PROGRESS).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K KISHI ET AL.: "METALLIC STENT TREATMENT IN THE ESOPHAGUS AND THE TREACHEOBRONCHUS" IGAKU NO AYUMI. 180. 701-704 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岸 和史: "食道と気管気管支に対する金属ステント治療" 医学のあゆみ. 180・11. 701-704 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岸 和史: "気管気管支狭窄症の治療のための再抜去可能生体適合自己拡張型ステントの開発" INNERVISION. 11・8. 10-10 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazushi Kishi: "A Dedicated Z-Stent for Acquired Saber-Sheath Tracheobronchomalacia" Cardiovascular and Interventional Radiology. 20. 462-465 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岸 和史: "食道と気管気管支に対する金属ステント治療" 医学のあゆみ. 180.11. 701-704 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岸 和史: "気管気管支狭窄症の治療のための再抜去可能生体適合自己拡張型ステントの開発" INNERVISION「インナービジョン」. 11・8. 10-10 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazushi Kishi: "A Dedicated Z-stent therapy for acquired saber sheath type tracheo bronchomalac" Cardio Vascular and Interventinal Radiology. 未定(ゲラ校正終了). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岸和史: "Z.Covered Z.Nitinol,PE=StentのBeagle気管内留置試験-第一報-" 日本医学放射線学会雑誌. 56(抄録). S130 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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