Measurement of fluorine compound (5-FU) in tumor by 19F-MRS.
| Project/Area Number |
07671035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
SHIKAURA Satiko Kansai Medical University, Faculty of Medicine, Assistant Professor, 医学部, 助手 (00178857)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Kenji Kansai Medical University, Faculty of Medicine, Assistant Professor, 医学部, 助手 (30247928)
寒川 光治 関西医科大学, 医学部, 助手 (10154684)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 19F-MRS / 5-FU / Experimental tumor / ^<19>F-MRS / 腫瘍 / 抗腫瘍効果 |
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| Research Abstract |
In this Study, We measure the chemical shift of 19-Fluorine on FdUMP, FuTP and 5-FU. We obtained 4.9 PPM at 5-FU in experimental mice tumor but it was difficult to separate measurement on FdUMP,FuTP and 5-FU. To obtain the chemical shift, it needs the higher magnetic field system over the 4.7 Tesla. We obtained the calibration curve to measure the 5-FU and 5-FU analogs. At In Vitro. But at In vivo, it was difficult to measure fluorine compound. Because such fluorine compound was very little in experimental mice tumor. And then we can not analyze the F-peak of FdUMP, FuTP and 5-FU.
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Report
(3 results)
Research Products
(6 results)
