| Project/Area Number |
07671038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kurume University |
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Principal Investigator |
HAYABUCHI Naofumi Kurume University School of Medicine, Professor, 医学部, 教授 (20108731)
|
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| Co-Investigator(Kenkyū-buntansha) |
KAMEYAMA Tadamitsu Kurume University School of Medicine, Professor, 医学部, 教授 (00080937)
HIRANO Minoru Kurume University, President, 医学部, 学長 (60080868)
OGO Etsuyo Kurume University School of Medicine, Assistant Professor, 医学部, 助手 (20204729)
TABUCHI Emi Kurume University School of Medicine, Assistant Professor, 医学部, 助手 (30197553)
JO Seiya Kurume University School of Medicine, Assistant Professor, 医学部, 助手 (30196662)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Malignant Lymphoma / Head and Neck Tumor / Radiotherapy / Xerostomia / Taste Disturbance / Subjective Disturbance / Objective Disturbance / 客観的障害 |
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| Research Abstract |
In order to evaluate xerostomia and taste disturbance after radiotherapy for patients with head and neck tumors including malignant lymphomas, retrospective study was made for 40 patients who had recieved radiotherapy 40 Gy or more to their head and neck region.
Subjective xerostomia was assessed using questionare that measured difficulty with eating, speech and sleep. To evaluate objective xerostomia, salivary gland juice was measured. Subjective xerostomia and objective one were well correlated each other and improved gradually.
Subjective taste disturbance was assessed similarly using questionare that measured difficulty with sweetness, hotness, sourness and bitterness. Taste disk was used to evaluate taste disturbance objectively. Subjective taste disturbance and objective one were well correlated each other and also improved gradually.
With these results, trial for protection against xerostomia and taste disturbance was started by using oral administration of pilocarpine and other drugs.
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