| Project/Area Number |
07671065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
YAMADA Naoto Shiga Univ Med Sci, Psychiatry, Associate Professor, 医学部, 助教授 (50166724)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Tadafumi Shiga Univ Med Sci, Psychiatry, Assistant, 医学部, 助手 (30214381)
村下 淳 滋賀医科大学, 医学部, 助手 (80252386)
塩入 俊樹 滋賀医科大学, 医学部, 助手 (40235487)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | MRS / Brain imaging / Bipolar disorder / phosphocreatine / sleep deprivation / Brain metabolism / 躁うつ病 / 磁気共鳴スペクトロスコピー / Magnctic Researce Spectroscopy(MRS) / エネルギー代謝 |
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| Research Abstract |
We developed the phosphorus-31 one-demensional chemical shift imaging (^<31>P-1DCSI) method and applied this method to the investigations of brain energy metabolism in patients with bipolar disorder. The phosphocreatine peak area was decreased in the left frontal lobe of bipolar patients and it was signficantly negatively correlated with scores of Hamilton Depression Rating Scale. This finding was not observed in other psychiatric disorders, such as major depression, schizophrenia, and panic disorder. We used proton magnetic resonance spectroscopy (^1H-MRS) to examine the left frontal lobe in bipolar patients and found that total creatine was decreased in this region, which confirmed the previous finding of phosphocreatine. We further examined the photic stimulation induced alteration of brain phosphorus metablism to examine subtle metabolic change in these patients. Bipolar patients had different reaction patterns to photic stimulation, which suggest trait-dependent abnormality of brain energy metabolism. To examine the mechanisms of action of sleep deprivation on bipolar depression, we investigated the effects of sleep deprivation on brain phosphorus metabolism in normal volunteers. There found a large inter-individual variation in metabolic response to sleep deprivation.
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