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Neuropsychological Study on the Cognitive Disorders of Chronic Alcoholics

Research Project

Project/Area Number 07671086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKeio University

Principal Investigator

KASHIMA Haruo  Keio University, School of Medicine Associat Professor, 医学部, 助教授 (70101954)

Co-Investigator(Kenkyū-buntansha) YOSHINO Fumihiro  Keio University, School of Medicine Clinical Instructor, 医学部, 助手 (00220707)
OOE Yasuo  Keio University, School of Medicine Senior Clinical Instructor, 医学部, 助手 (30185201)
吉益 晴夫  慶應義塾大学, 医学部・精神神経科学教室, 助手 (60240347)
斉藤 寿昭  慶應義塾大学, 医学部・精神神経科学教室, 助手 (60186947)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Keywordsalcoholism / memory disorder / problem solving ability / alcoholic dementia / Korsakoff syndrome / frontal dysfunction / neuropsychological assessment / Alcoholism / frontal function / memory disorder
Research Abstract

Cognitive performance of Japanese alcoholics (n=95) was compared with that of age-matched non-alcoholic controls (n=40) on eight tests of general congnitive ability, verbal and nonverbal memory, constructive ability, problem solving ability. Alcoholic subjects had been abstinent for 8-10 weeks at inpatients Alcohol Rehabilitation Programs and had no histories of severe head trauma, neurological disease or psychosis. Using one factor ANCOVA with age and education as the covariates, verbal and nonverbal memory impairment (retrieval deficits with interference) and deficit of problem solving ability were revealed in alcoholic subjects. Moreover, using the same method, effect of drinkin history on neuropsychologicai performance was investigated in alcoholic subjects. Long-term alcoholics had significant lower scores mainly in verbal and nonverbal memory tasks than short-term alcoholics. These results suggest that chronicity of alcoholism predicts the degree of memory disturbance.
"Alcoholic … More dementia" has long been a matter of controversy. We attempted to classify the types of the so-called "alcoholic dementia" based on the results of 11 neuropsychological tests. As alcoholic dementia in a broad sense, were selected 39 chronic alcoholics, who were abstinent for more than three months, and scored less than 23 points on Mini-Mental State Examination or showed clinical pictures of the deteriorated state. According to the pattern of test results could be identified 4 subtypes, i.e.Korsakoff syndrome type, severe Korsakoff syndrome type, frontal dysfunction type and whole cerebral dysfunction type. Of these 4 types severe Korsakoff syndrome type and whole dysfunction type are thought to correspond to "alcoholic dementia" in a narrow sense. All of these 4 types showed more or less the frontal dysfunction or amnesie de type axiale. This suggests that the cognitive disorders of chronic alcoholics including "alcohol dementia" in a narrow sense have close relations to the subcortical dementias. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 鹿島晴雄: "注意障害と前頭葉損傷" リハビリテーション医学. 32. 294-297 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鹿島晴雄: "前頭葉症状と神経心理学的評価" 脳と精神の医学. 6. 145-154 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鹿島晴雄他: "アルコール痴呆-神経心理学的類型について-" 日本アルコール精神医学雑誌. 2. 47-56 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鹿島晴雄他: "高次脳機能障害のリハビリテーションにおける“機能系の再編成"" Journal of Clinical Rehabilitation. 別冊. 14-19 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鹿島晴雄他: "前頭連合野と文脈記憶" Brain Medical. 7. 251-258 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 三村將,鹿島晴雄他: "前交通動脈瘤破裂後健忘症候群とアルコールコルサコフ症候群の神経心理学的検討" 臨床神経学. 35. 850-854 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Haruo Kashima et al.: "Frontal lobe and memory disorder (Chapter), Excerpta Medica" Elsevier, The Netherlands (in print), (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Haruo Kashima et al.: "Frontal lobe symptoms and neuropsychological assessment (Chapter)書名(The association cortices-Stracture and Fictions)" Gordon and Breach Science Publishors Inc, (in print), (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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