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Prospective study of rapid cycling affective disorder

Research Project

Project/Area Number 07671091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Women's Medical College

Principal Investigator

SAKAMOTO Kaoru  Tokyo Women's Medical College School of Medicine, Assistant Professor, 医学部, 講師 (30205760)

Co-Investigator(Kenkyū-buntansha) TOMITAKA Shinichiro  Tokyo Women's Medical College School of Medicine, Instructor, 医学部, 助手 (00237124)
KAMO Toshiko  Tokyo Women's Medical College School of Medicine, Assistant Professor, 医学部, 講師 (20186018)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
KeywordsRapid cycler / corisol / lithium / prognosis / 治療抵抗性
Research Abstract

To our knowledge, there are only two prospective studies which have investigated the prognosis of rapid cycling affective disorder and their results vary quite considerably. Thus, the prognostic significance of rapid cycling remains an important question.
We followed up 30 rapid cyclers who were treated aggressively with lithium, carbamazepine and sometimes in combination with other drugs. Of these 30, fourteen stopped cycling rapidly within the first year. On the other hand, the remaining sixteen comtinued to cycle rapidly. Their treatment responses differ accordingly to the duration of rapid cycling prior to intensive treatment.
We also assessed hypothalamic-pituitary-adrenocortical axis function in patients with rapid cycling by measuring urinary free cortisol in the dexamethasone test. Our results show that rapid cycling patients have lower urinary free cortisol levels during hypomanic phases than during depressive phases. The present study confirmed the hypothesis that hypothalamic-pituitrary-adrenocortical axis function varies with the mood states of rapid cycling patients.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Sakamoto Kaoru: "A longitudinal follow-up study of seaenal affective disorders" American Journal of Psychiatry. 152. 862-868 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomitaka Shin-ichiro: "Serial dexauicthasone suppression tests by mesuring urinary cevtisol among rapidly oprting patieats" Biological Psychiatry. 38. 128-130 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomitaka Shin-ichiro: "Pexamethasone-Suppresion Test by Measuring Spot Uvinavy Free Certisol in depression" Biological Psychiatry. 39. 220-222 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 坂元薫: "抗うつ薬の科学" 星和書店, 288 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sakamoto Kaoru, Nakadaira Susumu, Kamo Koji, Kamo Toshiko, .Takahashi Kiyohisa: "A longitudinal follow-up studyof seasonal affective discvder" American Journal of Psychiatry. 152. 862-868 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomitaka Shin-ichiro, Sakamoto Kaoru, Kojima Itaru, Fujita Hiroko: "Sevial dexamethasone suppresion tests by measaring urinary cortisol among rapidly cycling patients." Biological Psychiatn. 38. 128-130 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomitaka Shin-ichiro, Sakamoto Kaoru, Tamura Atsuko, Kojima Itaru, Fujita Hiroko: "Dexamethasone scppresion test by measuring spot urinary free cortisol in depression" Biological Psychiatry. 39. 220-222 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomitaka Shin-ichiro: "Dexamethasone Suppresion Test by Measuring Spot Urinary Free Cortisol in depression" Biological Psychiatry. 39. 220-222 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sakamoto Kaoru: "A longitudinal follow-up study of seasenal affective disovders" American Journal of Psychiatry. 152. 862-868 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomitaka Shin-ichiro: "Serial dexamethasone suppression tests by measuring urinary certisol among rapidly cycling patients" Biological Psychiatry. 38. 128-130 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 坂元 薫: "抗うつ薬の科学" 星和書店, 288 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2021-08-26  

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